为了评估不同乳腺癌亚型和治疗反应亚组中合成 MRI (syMRI) 松弛测量与表观扩散系数 (ADC) 图之间的相关性。 纳入了 263 名接受新辅助治疗 (NAT) 治疗且具有基线 MRI 的乳腺癌患者。通过分别在 T1/T2/PD 和 ADC 图上沿病变绘制感兴趣区域 (ROI) 来获得肿瘤注释。分别计算T1/T2/PD和ADC图的直方图特征，并分析每对相同特征之间的相关性。同时，比较不同 NAT 治疗反应组之间的特征，并评估其区分能力。在所有患者中，27 对特征中有 20 对呈弱相关（r = - 0.13-0.30）。对于三阴性乳腺癌（TNBC），病理完全缓解（pCR）组（r = 0.60-0.86）的PD图特征与ADC的相关性高于非pCR组（r = 0.30-0.43） ，并且 pCR 组中 ADC 和 PD 图的平均值强相关 (r = 0.86)。对于 HER2 阳性，pCR 组和非 pCR 组中几乎没有发现相关性。对于管腔 HER2 阴性，T2 图与 ADC 的相关性高于 T1 和 PD 图。 Luminal-HER2 阴性亚型的 T2 低百分位数和中位数存在显着差异，产生中等 AUC (0.68/0.72/0.71)。TNBC 中 ADC 和 PD 图之间的关系可能表明不同的 NAT 反应。 ADC 和 syMRI 之间的非弱相关性表明它们在肿瘤微环境评估中的互补作用。TNBC 中 ADC 和 PD 图之间的关系可能表明不同的 NAT 反应，ADC 和 syMRI 之间的非弱相关性表明它们在肿瘤微环境评估中发挥互补作用。 • TNBC 中 ADC 和 PD 之间的关系表明不同的 NAT 反应。 • ADC 和syMRI 之间的无至弱相关性可以互补地评估肿瘤微环境。 • T2 低百分位数和中位数预测管腔 HER2 阴性亚型的 NAT 反应。© 2023。欧洲放射学会 (ESR)。

To evaluate the correlation between synthetic MRI (syMRI) relaxometry and apparent diffusion coefficient (ADC) maps in different breast cancer subtypes and treatment response subgroups.Two hundred sixty-three neoadjuvant therapy (NAT)-treated breast cancer patients with baseline MRI were enrolled. Tumor annotations were obtained by drawing regions of interest (ROIs) along the lesion on T1/T2/PD and ADC maps respectively. Histogram features from T1/T2/PD and ADC maps were respectively calculated, and the correlation between each pair of identical features was analyzed. Meanwhile, features between different NAT treatment response groups were compared, and their discriminatory power was evaluated.Among all patients, 20 out of 27 pairs of features weakly correlated (r = - 0.13-0.30). For triple-negative breast cancer (TNBC), features from PD map in the pathological complete response (pCR) group (r = 0.60-0.86) showed higher correlation with ADC than that of the non-pCR group (r = 0.30-0.43), and the mean from the ADC and PD maps in the pCR group strongly correlated (r = 0.86). For HER2-positive, few correlations were found both in the pCR and non-pCR groups. For luminal HER2-negative, T2 map correlated more with ADC than T1 and PD maps. Significant differences were seen in T2 low percentiles and median in the luminal-HER2 negative subtype, yielding moderate AUCs (0.68/0.72/0.71).The relationship between ADC and PD maps in TNBC may indicate different NAT responses. The no-to-weak correlation between the ADC and syMRI suggests their complementary roles in tumor microenvironment evaluation.The relationship between ADC and PD maps in TNBC may indicate different NAT responses, and the no-to-weak correlation between the ADC and syMRI suggests their complementary roles in tumor microenvironment evaluation.• The relationship between ADC and PD in TNBC indicates different NAT responses. • The no-to-weak correlations between ADC and syMRI complementarily evaluate tumor microenvironment. • T2 low percentiles and median predict NAT response in luminal-HER2-negative subtype.© 2023. European Society of Radiology (ESR).