黑色素瘤是一种潜在致命的皮肤癌，由黑色素细胞无限增殖引起。黑素细胞谱系似乎具有更高的活性氧 (ROS) 产生率，这可能是由于暴露于紫外线 (UV) 和黑色素产生的结果。已确定核因子红细胞 2 相关因子 2 (Nrf2) 是细胞氧化应激反应的主要调节因子。最近的研究表明，Nrf2 及其关键负调节因子 Kelch 样 ECH 相关蛋白 1 (Keap1) 在黑色素瘤中受到错误调节，Keap1-Nrf2 通路已成为治疗和预防黑色素瘤的一个有前景的新靶点。在黑色素瘤中，Nrf2 可能限制肿瘤生长或促进其发展。这篇综述涵盖了广泛的主题，包括 Keap1-Nrf2 信号通路在黑色素瘤中发挥的双重功能以及 Nrf2 的最新靶向技术。© 2023 John Wiley

Melanoma is a potentially lethal form of skin cancer resulting from the unlimited proliferation of melanocytes. Melanocytic lineage appears to have a greater rate of reactive oxygen species (ROS) production, possibly as a result of exposure to ultraviolet (UV) light and the production of melanin. It has been established that nuclear factor erythroid 2-related factor 2 (Nrf2) serves as a master regulator of the cellular response to oxidative stresses. Recent research has shown that the Nrf2 and its critical negative regulator Kelch-like ECH-associated protein 1 (Keap1) are misregulated in melanoma, and the Keap1-Nrf2 pathway has emerged as a promising new target for treating and preventing melanoma. In melanoma, Nrf2 may either limit tumor growth or promote its development. This review covers a wide range of topics, including the dual functions played by the Keap1-Nrf2 signaling pathway in melanoma and the most recent targeting techniques of the Nrf2.© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.