受体酪氨酸激酶 (RTK) 介导的信号转导是细胞功能的基础，并驱动重要的细胞结果，当失调时，可能导致恶性肿瘤生长和转移。来自质膜结合 RTK 的信号的启动受到控制下游效应蛋白招募和功能的多种调控机制的影响。 RTK 很容易通过液-液相分离 (LLPS) 凝结成具有下游效应蛋白的无膜细胞器，这为信号调节提供了进一步的基本机制。在此，我们强调这种现象如何促进癌症信号传导，并考虑 LLPS 对癌症患者预后的潜在影响。版权所有 © 2023 作者。由爱思唯尔有限公司出版。保留所有权利。

Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity of RTKs to condense via liquid-liquid phase separation (LLPS) into membraneless organelles with downstream effector proteins provides a further fundamental mechanism for signal regulation. Herein we highlight how this phenomenon contributes to cancer signalling and consider the potential impact of LLPS on outcomes for cancer patients.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.