为了调查自我报告的步行速度 (SRWP) 与特定原因死亡的相对和绝对风险之间的关联。在 2006 年至 2010 年招募的 391,652 名英国生物银行参与者中，我们估计了性别和特定原因（心血管疾病 [CVD]、癌症） 、其他原因）死亡率风险比 (HR) 和 SRWP 类别（慢、平均、快）的 10 年死亡率风险，考虑了混杂因素和竞争风险。审查发生在 2021 年 9 月 30 日（英格兰、威尔士）和 2021 年 10 月 31 日（苏格兰）。在中位随访 12.6 年中，发生了 22,413 例死亡。在女性中，对于癌症、CVD 和其他死因，快 SRWP 与慢 SRWP 的比较 HR 分别为 0.74 (95% CI: 0.67, 0.82)、0.40 (0.33, 0.49) 和 0.29 (0.26, 0.32)。男性为 0.71 (0.64, 0.78)、0.38 (0.33, 0.44) 和 0.29 (0.26, 0.32)。与 CVD 相比，其他原因的 HR 较高（女性：39.6% [6.2, 72.9]；男性：31.6% [9.8, 53.5]），而癌症的 HR 较小（-45.8% [-58.3, -33.2] 和 - 45.9%）分别为[-54.8，-36.9]）。对于男女所有原因而言，慢步行者的 10 年死亡风险较高，但因性别、年龄和原因而异，导致快步行走与慢步行走的风险降低程度不同：最大的是 75 岁时因其他原因死亡的风险年[女性：-6.8%（-7.7，-5.8）；男性：-9.5% (-10.6, -8.4)]。与慢步行者相比，快走的 SRWP 与癌症（最小减少）、CVD 和其他（最大）死因减少相关，因此可能是一个有用的临床预测标记。由于绝对风险降低程度因年龄、原因和 SRWP 的不同而异，某些群体可能特别受益于增加 SRWP 的干预措施。版权所有 © 2023。由 Elsevier Inc. 出版。

To investigate associations of self-reported walking pace (SRWP) with relative and absolute risks of cause-specific mortality.In 391,652 UK Biobank participants recruited in 2006-2010, we estimated sex- and cause-specific (cardiovascular disease [CVD], cancer, other causes) mortality hazard ratios (HRs) and 10-year mortality risks across categories of SRWP (slow, average, brisk), accounting for confounders and competing risk. Censoring occurred in September 30, 2021 (England, Wales) and October 31, 2021 (Scotland).Over a median follow-up of 12.6 years, 22,413 deaths occurred. In women, the HRs comparing brisk to slow SRWP were 0.74 (95% CI: 0.67, 0.82), 0.40 (0.33, 0.49), and 0.29 (0.26, 0.32) for cancer, CVD, and other causes of death, respectively, and 0.71 (0.64, 0.78), 0.38 (0.33, 0.44), and 0.29 (0.26, 0.32) in men. Compared to CVD, HRs were greater for other causes (women: 39.6% [6.2, 72.9]; men: 31.6% [9.8, 53.5]) and smaller for cancer (-45.8% [-58.3, -33.2] and - 45.9% [-54.8, -36.9], respectively). For all causes in both sexes, the 10-year mortality risk was higher in slow walkers, but varied across sex, age, and cause, resulting in different risk reductions comparing brisk to slow: the largest were for other causes of death at age 75 years [women: -6.8% (-7.7, -5.8); men: -9.5% (-10.6, -8.4)].Compared to slow walkers, brisk SRWP was associated with reduced cancer (smallest reduction), CVD, and other (largest) causes of death and may therefore be a useful clinical predictive marker. As absolute risk reductions varied across age, cause, and SRWP, certain groups may particularly benefit from interventions to increase SRWP.Copyright © 2023. Published by Elsevier Inc.