覆盖范围：1925年至2023年7月在具有丰富结构多样性和潜在生物活性的倍半萜类化合物中，林烯烷倍半萜类化合物（LSs）具有特征性的顺式、反式3,5,6-碳环骨架，主要以单体和多种低聚物形式存在于林德拉属植物中和金粟兰科。自1925年首次从马钱子中鉴定出茚烯醇以来，已发现了354种具有抗炎、抗肿瘤和抗感染活性的天然LS及其低聚物。在结构上，三分之二的 LS 通过不同的聚合模式以具有有趣骨架的低聚物形式存在，特别是 Diels-Alder [4 2] 环加成。合成化学家对其多样化的生物活性和有趣的多环结构着迷，近几十年来一直致力于天然LS的全合成。本文对1925年至2023年7月LSs相关研究成果进行了系统、全面的总结，重点对其结构分类、化学合成和生物活性进行了阐述，有助于LSs及其低聚物的进一步研究。

Covering: 1925 to July 2023Among the sesquiterpenoids with rich structural diversity and potential bioactivities, lindenane sesquiterpenoids (LSs) possess a characteristic cis, trans-3,5,6-carbocyclic skeleton and mainly exist as monomers and diverse oligomers in plants from the Lindera genus and Chloranthaceae family. Since the first identification of lindeneol from Lindera strychnifolia in 1925, 354 natural LSs and their oligomers with anti-inflammatory, antitumor, and anti-infective activities have been discovered. Structurally, two-thirds of LSs exist as oligomers with interesting skeletons through diverse polymeric patterns, especially Diels-Alder [4 + 2] cycloaddition. Fascinated by their diverse bioactivities and intriguing polycyclic architectures, synthetic chemists have engaged in the total synthesis of natural LSs in recent decades. In this review, the research achievements related to LSs from 1925 to July of 2023 are systematically and comprehensively summarized, focusing on the classification of their structures, chemical synthesis, and bioactivities, which will be helpful for further research on LSs and their oligomers.