松果菊苷是一种天然苯乙醇苷，大约六十年前从属于菊科的园林植物狭叶紫锥菊 (Echinacea angustifolia DC.) 中发现并分离出来。广泛的研究表明，它具有多种对人类健康有益的药理学活性，特别是其神经保护和抗癌活性。几个关键问题浮出水面，包括对原型形式生物利用度不足的活性代谢物的识别、与松果菊苷上述作用相关的精确分子信号通路或靶点的建立，以及可靠临床试验的稀缺。因此，科学研究是否能够有效利用这种天然化合物的问题仍然没有答案。为了支持对这种天然产品的未来研究，必须对潜在的未来前景提供系统的概述和见解。本综述对松果菊苷的现有知识进行了全面分析，包括其广泛分布、结构多样性和代谢、多样化的治疗应用以及其潜在利用的松果菊苷生物利用度的改进。版权所有 © 2023。由 Elsevier Ltd 出版。

Echinacoside, a natural phenylethanoid glycoside, was discovered and isolated from the garden plant Echinacea angustifolia DC., belonging to the Compositae family, approximately sixty years ago. Extensive investigations have revealed that it possesses a wide array of pharmacologically beneficial activities for human health, particularly notable for its neuroprotective and anticancer activity. Several crucial concerns surfaced, encompassing the recognition of active metabolites that exhibited inadequate bioavailability in their prototype form, the establishment of precise molecular signal pathways or targets associated with the aforementioned effects of echinacoside, and the scarcity of dependable clinical trials. Hence, the question remains unanswered as to whether scientific research can effectively utilize this natural compound. To support future studies on this natural product, it is imperative to provide a systematic overview and insights into potential future prospects. The current review provides a comprehensive analysis of the existing knowledge on echinacoside, encompassing its wide distribution, structural diversity and metabolism, diverse therapeutic applications, and improvement of echinacoside bioavailability for its potential utilization.Copyright © 2023. Published by Elsevier Ltd.