MECOM 基因座编码的亲嗜性病毒整合位点 1 (EVI1) 是一种致癌锌指转录因子，在正常和恶性细胞中具有多种作用，在造血过程中得到最广泛的研究。 EVI1以上下文依赖性方式与其他转录因子相互作用，调节转录和染色质重塑，从而影响细胞的增殖、分化和存活。有趣的是，它既可以充当转录激活子，也可以充当转录抑制子。 EVI1在神经系统和造血等不同组织的发育过程中表达并发挥重要功能，表现出严格的时空表达模式。然而，EVI1 在多种癌症实体中经常过度表达，包括卵巢癌和胰腺癌等上皮癌，以及骨髓性白血病等血液恶性肿瘤。重要的是，EVI1 过度表达通常与非常差的临床结果和治疗抵抗相关。因此，EVI1 是一个有趣的候选者，可用于研究改善“EVI1high”造血系统恶性肿瘤高危患者的预后和治疗。版权所有 © 2023 作者。由 Wolters Kluwer Health, Inc. 代表欧洲血液学协会出版。

Ecotropic viral integration site 1 (EVI1), encoded at the MECOM locus, is an oncogenic zinc finger transcription factor with diverse roles in normal and malignant cells, most extensively studied in the context of hematopoiesis. EVI1 interacts with other transcription factors in a context-dependent manner and regulates transcription and chromatin remodeling, thereby influencing the proliferation, differentiation, and survival of cells. Interestingly, it can act both as a transcriptional activator as well as a transcriptional repressor. EVI1 is expressed, and fulfills important functions, during the development of different tissues, including the nervous system and hematopoiesis, demonstrating a rigid spatial and temporal expression pattern. However, EVI1 is regularly overexpressed in a variety of cancer entities, including epithelial cancers such as ovarian and pancreatic cancer, as well as in hematologic malignancies like myeloid leukemias. Importantly, EVI1 overexpression is generally associated with a very poor clinical outcome and therapy-resistance. Thus, EVI1 is an interesting candidate to study to improve the prognosis and treatment of high-risk patients with "EVI1high" hematopoietic malignancies.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.