白细胞介素17（IL-17）家族由六个成员（IL-17A-17F）组成，最近，其所有相关受体均已被发现。 IL-17 首次被发现是在大约 30 年前。该家族的成员具有多种生物学功能，包括在感染和自身免疫性疾病期间驱动炎症级联反应，以及增强针对各种病原体的保护性免疫力。 IL-17 是一种高度通用的促炎细胞因子，是宿主免疫防御、组织修复、炎症性疾病发病机制和癌症进展等重要过程所必需的。然而，IL-17 如何发挥这些功能仍存在争议。 IL-17的多功能特性引起了研究兴趣，不断出现的数据逐渐提高了我们对IL-17信号通路的理解。然而，需要进行全面的审查以了解其在宿主防御功能和体内发病机制中的作用。该综述可以帮助研究人员更好地理解IL-17在体内作用的机制，并为未来旨在调节IL-17表达和功能的研究提供理论基础。本综述讨论了了解 IL-17 信号通路及其生理作用的最新进展。此外，我们还介绍了 IL-17 在各种病理学中的作用机制，特别是在 IL-17 诱导的系统性红斑狼疮和 IL-17 相关的肿瘤细胞转化和转移中。此外，我们还简要讨论了自身免疫性疾病和肿瘤的诊断和治疗方面的有希望的发展。© 2023。四川大学华西医院。

The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, how IL-17 performs these functions remains controversial. The multifunctional properties of IL-17 have attracted research interest, and emerging data have gradually improved our understanding of the IL-17 signaling pathway. However, a comprehensive review is required to understand its role in both host defense functions and pathogenesis in the body. This review can aid researchers in better understanding the mechanisms underlying IL-17's roles in vivo and provide a theoretical basis for future studies aiming to regulate IL-17 expression and function. This review discusses recent progress in understanding the IL-17 signaling pathway and its physiological roles. In addition, we present the mechanism underlying IL-17's role in various pathologies, particularly, in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and metastasis. In addition, we have briefly discussed promising developments in the diagnosis and treatment of autoimmune diseases and tumors.© 2023. West China Hospital, Sichuan University.