这项回顾性研究旨在描述和确定保护区内非家养猫科动物脊柱疾病的患病率。对 2003 年至 2021 年 304 份豹属物种尸检报告的审查显示，86/304 (28%) 被诊断患有脊柱疾病。脊柱病变根据病理过程进行分类：退行性（78/86，91%）、发育性（8/86，9%）、炎症性（6/86，7%）或肿瘤性（8/86，9%）。退行性病变包括椎间盘疾病（IVDD；66/78，85%）、不并发 IVDD 的脊椎病（4/78，5%）和特发性（非压缩性）退行性脊髓病（8/78，10%）。 14 个人有超过 1 类病变。发育病例为椎骨（4/8）或脊髓（3/8）畸形或两者兼而有之（1/8）。炎症病变包括脑膜炎（4/6）和脑膜脊髓炎（2/6）。肿瘤包括椎体多发性骨髓瘤（4/8）和其他肿瘤（4/8）。 IVDD 通常累及多个椎间盘，但主要影响颈椎（41/66，62%）和胸椎（32/66，48%）。多变量二元逻辑模型预测了尸检时 IVDD 的诊断，其中雄性、狮子 (Panthera leo) 和老年年龄组 (>14 岁) 受影响的几率最高。本研究中记录的脊柱病变提供了对高风险信号类别和影响圈养豹种群的主要相关病变的深入了解。具体来说，脊柱疾病，尤其是颈椎 IVDD，在豹属物种中很常见，而狮子、雄性和年长的猫科动物的风险更高。

This retrospective study aimed to characterize and determine the prevalence of spinal disease in nondomestic felids within a sanctuary population. A review of 304 postmortem examination reports in Panthera species from 2003 to 2021 revealed that 86/304 (28%) were diagnosed with spinal disease. Spinal lesions were categorized according to pathologic process: degenerative (78/86, 91%), developmental (8/86, 9%), inflammatory (6/86, 7%), or neoplastic (8/86, 9%). Degenerative lesions included intervertebral disk disease (IVDD; 66/78, 85%), spondylosis without concurrent IVDD (4/78, 5%), and idiopathic (noncompressive) degenerative myelopathies (8/78, 10%). Fourteen individuals had lesions in more than 1 category. Developmental cases were vertebral (4/8) or spinal cord (3/8) malformations or both (1/8). Inflammatory lesions included meningitis (4/6) and meningomyelitis (2/6). Neoplasia included vertebral multiple myeloma (4/8) and others (4/8). IVDD often involved multiple disks but primarily affected the cervical (41/66, 62%) and thoracic spine (32/66, 48%). A multivariate binary logistic model predicted the diagnosis of IVDD at postmortem examination, where odds of being affected were highest for males, lions (Panthera leo), and geriatric age group (>14 years). The spinal lesions documented in this study provide insight into high-risk signalment categories and predominant associated lesions affecting captive Panthera populations. Specifically, spinal disease, especially cervical IVDD, is common among Panthera species, and lions, males, and older felids are at increased risk.