本研究旨在确定接受根治性前列腺切除术 (RP) 的非洲裔美国人 (AAM) 和白人男性 (CM) 之间前列腺癌列线图调整的生化复发 (BCR) 和/或不良病理 (AP) 风险是否存在差异。对 2015 年至 2021 年间在宾夕法尼亚泌尿科区域协作组织中接受 RP 的男性进行了回顾性审查。Cox 比例风险回归模型用于比较 RP 后的 BCR 率，逻辑回归模型用于比较 RP 后的 AP 率CM 和 AAM，根据 CAPRA、CAPRA-S 和 MSKCC 术前和术后列线图评分进行调整。分别对符合纳入标准的 3190 名和 5029 名男性进行了 RP 后的 BCR 和 AP 率分析。与 CM (79.0%) 相比，AAM 的 2 年无 BCR 生存率 (72.5%) 较低，风险比 (HR) 为 1.38 (95% CI 1.16-1.63，p<0.001)。调整 MSKCC 术前（HR 1.29；95% CI 1.08-1.53​​；p = 0.004）和术后列线图（HR 1.26；95% CI 1.05-1.49）后，AAM 中的 BCR 率显着高于 CM ；p < 0.001）。调整 CAPRA（HR 1.13；95% CI 0.95-1.35；p = 0.17）和 CAPRA-S 列线图（HR 1.11；95% 0.93-1.32；p = 0.25）后，AAM 中的 BCR 率呈较高趋势，这未达到统计学显着性。调整 CAPRA（OR 1.28；95% CI 1.10-1.50；p = 0.001）和 MSKCC 列线图（OR 1.23；95% CI 1.06-1.43；p = 0.007）后，AAM 中的 AP 率显着高于 CM。对大型多中心队列的分析提供了进一步的证据，表明 RP 后 AAM 的 BCR 和 AP 率可能高于 CAPRA 和 MSKCC 列线图的预测。因此，AAM 可能会受益于更密切的术后监测，并且可能更有可能需要挽救治疗。© 2023。作者，获得 Springer Nature Limited 的独家许可。

This study aims to determine if there is a difference in prostate cancer nomogram-adjusted risk of biochemical recurrence (BCR) and/or adverse pathology (AP) between African American (AAM) and Caucasian men (CM) undergoing radical prostatectomy (RP).A retrospective review was performed of men undergoing RP in the Pennsylvania Urologic Regional Collaborative between 2015 and 2021. Cox proportional hazard regression models were used to compare the rate of BCR after RP, and logistic regression models were used to compare rates of AP after RP between CM and AAM, adjusting for the CAPRA, CAPRA-S, and MSKCC pre- and post-operative nomogram scores.Rates of BCR and AP after RP were analyzed from 3190 and 5029 men meeting inclusion criteria, respectively. The 2-year BCR-free survival was lower in AAM (72.5%) compared to CM (79.0%), with a hazard ratio (HR) of 1.38 (95% CI 1.16-1.63, p < 0.001). The rate of BCR was significantly greater in AAM compared to CM after adjustment for MSKCC pre-op (HR 1.29; 95% CI 1.08-1.53; p = 0.004), and post-op nomograms (HR 1.26; 95% CI 1.05-1.49; p < 0.001). There was a trend toward higher BCR rates among AAM after adjustment for CAPRA (HR 1.13; 95% CI 0.95-1.35; p = 0.17) and CAPRA-S nomograms (HR 1.11; 95% 0.93-1.32; p = 0.25), which did not reach statistical significance. The rate of AP was significantly greater in AAM compared to CM after adjusting for CAPRA (OR 1.28; 95% CI 1.10-1.50; p = 0.001) and MSKCC nomograms (OR 1.23; 95% CI 1.06-1.43; p = 0.007).This analysis of a large multicenter cohort provides further evidence that AAM may have higher rates of BCR and AP after RP than is predicted by CAPRA and MSKCC nomograms. Accordingly, AAM may benefit with closer post-operative surveillance and may be more likely to require salvage therapies.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.