纳米级结构已被开发用于癌症治疗中的各种功能，包括诊断、生物医学可视化、组织再生和药物输送等领域。基于生物相容性壳寡糖（COS）和金纳米棒（GNRs），我们设计了药物递送系统（GNR@聚丙烯酸-Mn@COS Janus纳米颗粒（JNPs）），实现了在GNRs侧面负载紫杉醇（PTX）， PAA-Mn结构域用作磁共振成像造影剂。研究发现，该系统通过增强渗透性和滞留（EPR）效应以及 COS 的主动靶点，有效地递送至肿瘤部位。均匀的 JNP 通过与肿瘤表面的 COS 相互作用，选择性地靶向癌细胞而不是正常细胞。细胞的pH/NIR响应性药物释放行为进一步增强了它们的治疗效果。使用皮下和原位肺转移模型评估了 JNP 对肿瘤的体内作用，为肿瘤诊断和癌症治疗带来了有希望的结果。总之，所获得的 JNP 作为具有协同化疗和光热效应的治疗诊断纳米平台具有广阔的前景。

Nanoscale structures have been developed to serve various functions in cancer therapy, encompassing areas such as diagnosis, biomedical visualization, tissue regeneration, and drug delivery. Based on biocompatible chitosan oligosaccharides (COS) and gold nanorods (GNRs), we designed the drug delivery systems (GNR@polyacrylic acid-Mn@COS Janus nanoparticles (JNPs)), which achieved paclitaxel (PTX) loaded on the side of GNRs, and the PAA-Mn domain served as magnetic resonance imaging contrast agents. This system was found to be effectively delivered to tumor sites through the enhanced permeability and retention (EPR) effect and the active target of the COS. The uniform JNPs selectively targeted cancer cells instead of normal cells through interacting with the COS on the surface of tumor cells, and the pH/NIR-responsive drug release behavior further enhanced their therapeutic effects. The in vivo effects of JNPs against tumors were evaluated using subcutaneous and orthotopic lung metastasis models, yielding promising outcomes for both tumor diagnosis and cancer treatment. In conclusion, the obtained JNPs hold great promise as a theranostic nanoplatform with synergistic chemotherapeutic and photothermal effects.