研究动态
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癌症相关内脏静脉血栓形成:诊断时的临床特征和短期结果。

Cancer-associated splanchnic vein thrombosis: Clinical features upon diagnosis and short-term outcomes.

发表日期:2023 Oct 09
作者: Adrián García-Villa, Juan José Criado-Álvarez, María Carnevali, Mario Aramberri, Carme Font, Carmen Díaz-Pedroche
来源: THROMBOSIS RESEARCH

摘要:

近年来,癌症患者内脏静脉血栓(SVT)的发病率有所增加,其真正的临床意义和治疗可能具有挑战性。本研究旨在描述癌症相关 SVT 患者的临床表现和短期结果。这是一项对 2015 年至 2020 年期间诊断出的连续癌症相关 SVT 患者的回顾性观察研究。主要目的是描述 SVT 的临床表现。根据 SVT 诊断时出现的症状,患者在临床上被分为两组。主要结局是总体死亡率和 SVT 相关死亡率、大出血率和非大出血率以及随访前 30 天的血栓复发率。这项研究纳入了 203 名患者。腹内肿瘤 (76%) 和转移性疾病 (68%) 占主导地位。共有 79 名(39%)没有症状的患者在预定的放射学检查中被诊断为 SVT,并被归类为“无症状”,而 124 名(61%)患者出现了一些潜在的 SVT 症状,并被视为“有症状”。尽管 30 天结果显示两组之间没有显着差异,但无症状组的死亡率略低于有症状组(3% vs. 10%,p = 0.085)。几乎 40% 的病例与癌症相关SVT 无症状。有症状和无症状患者的短期结果没有显着差异。需要更多的研究来更好地确定这些患者的长期治疗和结果。版权所有 © 2023 Elsevier Ltd。保留所有权利。
The incidence of splanchnic vein thrombosis (SVT) in cancer patients has increased in recent years and its real clinical significance and management can be challenging. This study aimed to describe the clinical presentation and short-term outcomes of patients with cancer-associated SVT.This was a retrospective observational study of consecutive patients with cancer-associated SVT diagnosed during the period 2015-2020. The primary objective was to describe the clinical presentation of SVT. Patients were clinically classified into two groups based on the presence of symptoms on SVT diagnosis. The main outcomes were overall and SVT-related mortality, major and non-major bleeding rates, and the thrombosis recurrence rate in the first 30 days of follow-up.This study enrolled 203 patients. Intra-abdominal tumors (76 %) and metastatic disease (68 %) predominated. A total of 79 (39 %) patients without symptoms were diagnosed with SVT during a scheduled radiological test and were classified as "asymptomatic", while 124 (61 %) patients presented some potential SVT symptoms and were considered as "symptomatic". Although the 30-day outcomes showed no significant differences between the two groups, mortality in the asymptomatic group was slightly lower compared to the symptomatic group (3 % vs. 10 %, p = 0.085).Almost 40 % of cases of cancer-associated SVT are asymptomatic. There were no significant differences in short-term outcomes between the symptomatic and asymptomatic patients. More studies are required to better define long-term management and outcomes in these patients.Copyright © 2023 Elsevier Ltd. All rights reserved.