MYC是一种主要的致癌转录因子，调节参与细胞增殖、代谢和免疫逃避等多种途径的靶基因，在多种癌症的肿瘤发生和发展中发挥着关键作用。在肝癌中，MYC及其信号通路发生显着变化，对肝癌进展产生深远影响，包括肿瘤增殖、转移、去分化、代谢、免疫微环境和综合治疗耐药等。这使得 MYC 成为一个有吸引力的靶点，尽管它之前被认为是一种不可成药的蛋白质。在这篇综述中，我们讨论了MYC在肝脏生理、慢性肝病、肝癌发生和肝癌进展中的作用和机制，为将MYC作为肝癌的理想治疗靶点提供理论基础。我们还总结并展望了针对 MYC 的策略，包括直接和间接消除 MYC 在肝癌中的致癌功能的方法。© 2023。作者，获得 Springer Nature Limited 的独家许可。

MYC, a major oncogenic transcription factor, regulates target genes involved in various pathways such as cell proliferation, metabolism and immune evasion, playing a critical role in the tumor initiation and development in multiple types of cancer. In liver cancer, MYC and its signaling pathways undergo significant changes, exerting a profound impact on liver cancer progression, including tumor proliferation, metastasis, dedifferentiation, metabolism, immune microenvironment, and resistance to comprehensive therapies. This makes MYC an appealing target, despite it being previously considered an undruggable protein. In this review, we discuss the role and mechanisms of MYC in liver physiology, chronic liver diseases, hepatocarcinogenesis, and liver cancer progression, providing a theoretical basis for targeting MYC as an ideal therapeutic target for liver cancer. We also summarize and prospect the strategies for targeting MYC, including direct and indirect approaches to abolish the oncogenic function of MYC in liver cancer.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.