多项流行病学研究表明睡眠质量与口腔疾病风险之间存在潜在关联，但由此得出的结论仍然存在争议，而且因果关系的存在仍然模棱两可。在本研究中，我们旨在调查睡眠时间、失眠和常见口腔疾病之间的因果关系。我们根据睡眠时间全基因组关联研究的汇总统计数据，利用遗传相关性和两样本孟德尔随机化分析（N = 460,099） ）、失眠（N = 462,341）、口腔溃疡（N = 385,026）、口腔癌（N = 4,151）和牙周病（N = 527,652）。我们的研究结果显示，睡眠时间和口腔溃疡之间存在负遗传相关性（遗传）相关性：-0.09，P = 0.007），而失眠与口腔溃疡之间存在正向遗传相关性（遗传相关性：0.18，P = 2.51E-06）。此外，我们还证明，较长的睡眠时间与口腔溃疡风险降低显着相关（OR：0.67，95% CI：0.54-0.83，P = 2.84E-04），而失眠名义上与口腔溃疡风险增加相关。溃疡（OR：1.40，95% CI：1.01-1.95，P = 0.044）。相比之下，睡眠质量与牙周病或口腔癌之间没有发现显着关联。这项工作提供了强有力的证据来支持这样的观点，即提高睡眠质量可能会降低口腔溃疡的风险，从而具有相当大的临床相关性。© 2023。 BioMed Central Ltd.，隶属于施普林格自然。

Multiple epidemiological studies have posited a potential association between sleep quality and the risk of oral diseases, yet the resulting conclusions have remained contentious, and the presence of a causal link remains equivocal. In this study, we aimed to investigate the causal relationship between sleep duration, insomnia, and common oral diseases.We utilized genetic correlation and two-sample Mendelian randomization analyses based on summary statistics from genome-wide association studies of sleep duration (N = 460,099), insomnia (N = 462,341), mouth ulcer (N = 385,026), oral cavity cancer (N = 4,151), and periodontal disease (N = 527,652).Our results revealed a negative genetic correlation between sleep duration and mouth ulcer (genetic correlation: -0.09, P = 0.007), while a positive genetic correlation between insomnia and mouth ulcer was observed (genetic correlation: 0.18, P = 2.51E-06). Furthermore, we demonstrated that longer sleep duration is significantly associated with a reduced risk of mouth ulcers (OR: 0.67, 95% CI: 0.54-0.83, P = 2.84E-04), whereas insomnia is nominally associated with an increased risk of mouth ulcers (OR: 1.40, 95% CI: 1.01-1.95, P = 0.044). In contrast, no significant association was detected between sleep quality and periodontal disease or oral cavity cancer.This work provides robust evidence to support the notion that enhanced sleep quality may confer a decreased risk of oral ulcers, thereby bearing considerable clinical relevance.© 2023. BioMed Central Ltd., part of Springer Nature.