南欧大西洋饮食及其补充剂:其抗癌特性的化学基础。
The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties.
发表日期:2023 Oct 06
作者:
Pablo García Vivanco, Pablo Taboada, Alberto Coelho
来源:
GENOMICS PROTEOMICS & BIOINFORMATICS
摘要:
科学证据越来越多地支持饮食与健康之间的密切联系,承认均衡的饮食在预防肥胖、糖尿病、心血管问题和某些类型的癌症等慢性疾病方面发挥着至关重要的作用。这一观点为开发精准饮食打开了大门,特别是针对有患癌症风险的个体。它涵盖了广阔的研究领域,涉及对具有多级“组学”组成的不断扩大的化合物的研究,包括基因组学、转录组学、蛋白质组学、表观基因组学、miRNA组学和代谢组学。我们从化学和药理学的角度回顾了南欧大西洋饮食 (SEAD) 的成分。查阅的信息来源,辅以蛋白质数据库的晶体学数据,在 SEAD 及其抗癌特性之间建立了直接联系。收集到的数据强烈表明 SEAD 具有异常健康的特点,特别是因为其食品中含有有益的生物分子。在这种饮食中加入橄榄油和辣椒粉可带来许多健康益处,科学证据支持含有源自芸苔属蔬菜的生物分子的膳食补充剂的抗癌特性。尽管如此,该领域仍需进一步研究,以更深入地了解 SEAD 生物活性化合物抗癌的潜在益处。
Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision diets, particularly tailored for individuals at risk of developing cancer. It encompasses a vast research area and involves the study of an expanding array of compounds with multilevel "omics" compositions, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. We review here the components of the Southern European Atlantic Diet (SEAD) from both a chemical and pharmacological standpoint. The information sources consulted, complemented by crystallographic data from the Protein Data Bank, establish a direct link between the SEAD and its anticancer properties. The data collected strongly suggest that SEAD offers an exceptionally healthy profile, particularly due to the presence of beneficial biomolecules in its foods. The inclusion of olive oil and paprika in this diet provides numerous health benefits, and scientific evidence supports the anticancer properties of dietary supplements with biomolecules sourced from vegetables of the brassica genus. Nonetheless, further research is warranted in this field to gain deeper insights into the potential benefits of the SEAD's bioactive compounds against cancer.