本研究评估了与口腔扁平苔藓 (OLP) 潜在恶性进化相关的微小 RNA (miRNA) 的口腔组织表达。此外，还评估了 OLP 严重程度与 miRNA 表达之间的相关性，并确定了 OLP 患者中 miRNA 的可能预测因子。本研究纳入了 41 名 OLP 患者（中位年龄 58 岁）和 42 名健康对照者（中位年龄 59 岁）。每个患者的 miRNA 水平（miR-7a-3p、-7a2-3p、-7a-5p、-21-3p、-21-5p、-100-3p、-100-5p、-125b-2-3p、 -125b-5p、-200b-3p、-200b-5p）通过逆转录聚合酶链式反应进行评估和分析。使用记忆问卷报告每位患者的临床参数以及最终出现的 OLP 症状、体征和疾病严重程度评分。与健康对照相比，OLP 患者表现出显着较高的 miR-7a-3p、-7a-2-3p、 -21-3p、miR-21-5p 和 miR-100-5p 水平 (p < 0.05)，并且显着降低 miR-125b-2-3p、-125b-5p、-200b-3p 和 -200b-5p 水平（ p < 0.05）。此外，OLP症状和体征与疾病严重程度评分显着相关，也是所有分析的miRNA的预测因子（p< 0.05）。与健康受试者相比，OLP患者表现出不平衡的口腔miRNA表达，与OLP潜在恶性进化的风险相关。此外，一些 miRNA 与 OLP 程度相关，并且是 OLP 症状、体征和疾病严重程度评分的重要预测因子。© 2023 作者。 《口腔疾病》由 Wiley periodicals LLC 出版。

The present study evaluated the oral tissue expression of micro-RNA (miRNAs) linked to the potential malignant evolution of oral lichen planus (OLP). Furthermore, the correlation between OLP severity and miRNAs expression was assessed, and possible predictors of miRNAs in OLP patients were identified.The present study enrolled 41 patients with OLP (median age 58 years) and 42 healthy controls (median age 59 years). In each patient, miRNA levels (miR-7a-3p,-7a2-3p,-7a-5p,-21-3p,-21-5p,-100-3p,-100-5p,-125b-2-3p,-125b-5p,-200b-3p,-200b-5p) were assessed and analyzed through reverse transcription polymerase chain reaction. Clinical parameters and the eventual presence of OLP symptoms, signs, and disease severity scores in each patient were reported using an anamnestic questionnaire.In comparison with healthy controls, OLP patients showed significantly higher miR-7a-3p,-7a-2-3p,-21-3p, miR-21-5p and miR-100-5p levels (p < 0.05) and significantly lower miR-125b-2-3p,-125b-5p,-200b-3p, and -200b-5p levels (p < 0.05). Furthermore, OLP symptoms and signs and disease severity scores were significantly correlated and were also predictors of all analyzed miRNAs (p < 0.05).In comparison with healthy subjects, OLP patients exhibited unbalanced oral miRNAs expression linked to the risk of potential malignant evolution of OLP. Furthermore, some miRNAs were correlated with OLP extent and were significant predictors of OLP symptoms, signs, and disease severity scores.© 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.