旨在描述口腔舌癌 (OTC) 部分舌切除术后感觉功能的变化，并确定舌尖感觉丧失 (LoTTS) 的预测因子。纳入原发性 OTC 部分舌切除术后至少三个月随访的患者。所有患者都接受了定性舌感觉评估和原生舌尖的客观舌感觉检查。收集了有关肿瘤切除、手术重建和病理阶段的更多详细信息。使用多元线性和逻辑回归进行统计分析。 纳入了 64 名患者，其中包括 34 名 (53%) 男性，入组时中位年龄为 65 岁。十名 (15%) 患者报告了 LoTTS。在多变量分析中，切除深度 (DOR) 的增加是 LoTTS 的独立预测因素，阈值为 1.3 cm 时风险增加。在我们的定性舌头评估中，LoTTS 还与较差的主观生活质量和感知言语表现相关。在这项初步研究中，我们发现 DOR 是预测治疗后功能的关键预后因素。 DOR 增加（尤其是超过 1.3 厘米）的患者发生 LoTTS 和相关发病的风险最大。这些发现可用于预测术后感觉缺陷、管理患者的期望并优化重建方法。需要未来的研究来验证和复制我们的结果。版权所有 © 2023 Elsevier Ltd。保留所有权利。

To characterize the change in sensory function following partial glossectomy for oral tongue cancer (OTC) and to identify predictors of loss of tongue-tip sensation (LoTTS).Patients with at least three months follow-up after partial glossectomy for primary OTC were included. All patients underwent a qualitative tongue sensation assessment and an objective tongue sensory exam of the native tongue tip. Additional details regarding the oncologic resection, surgical reconstruction, and pathological stage were collected. Multiple linear and logistic regressions were used for statistical analysis.Sixty-four patients were enrolled, including 34 (53%) men with a median age of 65 at enrollment. Ten (15%) patients reported LoTTS. Increased depth of resection (DOR) was an independent predictor of LoTTS on multivariate analysis, with an increased risk at a threshold of 1.3 cm. LoTTS was also associated with worse subjective quality of life and perceptive speech performance in our qualitative tongue assessment.In this pilot study, we found that DOR is a critical prognostic factor in predicting post treatment function. Patients with an increased DOR, particularly above 1.3 cm, are at greatest risk of LoTTS and associated morbidity. These findings may be used to predict post-operative sensory deficits, manage patients' expectations, and optimize the reconstructive approach. Future studies are needed to validate and replicate our results.Copyright © 2023 Elsevier Ltd. All rights reserved.