接触氡气与肺癌和其他肺部疾病有关。尽管在生物学上是合理的，但住宅氡气暴露与中风风险相关的研究却很少。研究参与者来自 REGARDS（中风地理和种族差异的原因）队列 (n=30 239)，其中包括男性和女性非西班牙裔45 岁及以上的黑人和白人成年人。排除基线中风和短暂性脑缺血发作的参与者，并缺少有关暴露和感兴趣结果的信息后，最终样本量为 26 950。主要结果是截至 2020 年 9 月 30 日首次缺血性中风的时间。县级氡气测量来自劳伦斯伯克利国家实验室的研究人员根据地理编码的居住历史与每个参与者建立了联系。我们使用具有时间依赖性暴露的 Cox 比例风险回归模型来估计该关联的风险比和 95% CI。在控制了包括人口、生活方式、临床变量和 PM2.5 在内的潜在混杂因素后，氡暴露与从不吸烟者中发生缺血性中风（风险比，1.39 [95% CI，1.01-1.90]），但在曾经吸烟者中则不然。当使用州/环境保护局住宅氡气调查中的氡气测量值时，结果在敏感性分析中大体一致。这项研究的结果表明，住宅氡气暴露与缺血性中风发病率之间的关联因吸烟状况而异，并且在从不吸烟的情况下可能很突出。 -吸烟者。需要进一步研究纳入室内氡测量来证实这些发现。

Exposure to radon has been linked to lung cancer and other lung diseases. Although biologically plausible, research of residential radon exposure in relation to stroke risk is scarce.Study participants were from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) cohort (n=30 239), which consisted of male and female non-Hispanic Black and White adults aged 45 and older. After excluding participants with baseline stroke and transient ischemic attack, and missing information on exposure and outcome of interest, the final sample size was 26 950. The primary outcome was time to the first ischemic stroke through September 30, 2020. County-level radon measures from Lawrence Berkeley National Laboratory were linked to each participant based on their geocoded residential history. We used Cox proportional hazards regression models with a time-dependent exposure to estimate hazard ratios and 95% CIs for the association.After controlling for potential confounding factors including demographic, lifestyle, clinical variables, and PM2.5, radon exposure was significantly associated with incident ischemic stroke among never-smokers (hazard ratio, 1.39 [95% CI, 1.01-1.90]) but not ever-smokers. The results were generally consistent in the sensitivity analysis when using radon measures from state/Environmental Protection Agency residential radon survey.Findings from this study suggest that the association between residential radon exposure and incidence of ischemic stroke varies by smoking status and may be prominent in never-smokers. Further studies incorporating indoor-radon measures are needed to confirm these findings.