上皮组织稳态与上皮干细胞（ESC）的自我更新和分化行为密切相关。 p63是ESCs的众所周知的标志物，是其在上皮发育过程中发挥生物学活性不可或缺的因素。 p63 同种型在不同组织中表达的多样性使得该转录因子具有广泛的作用。 p63 协调参与细胞存活、干细胞自我更新、迁移、分化和上皮间质转化的基因转录。通过调节这些生物过程，p63 不仅有助于正常上皮发育，还有助于上皮衍生的癌症发病机制。在这篇综述中，我们概述了 p63 在上皮干性调节中的作用，包括自我更新、分化、增殖和衰老。我们描述了 TAp63 和 ΔNp63 亚型的差异表达及其在正常上皮组织和上皮源性肿瘤中的独特功能活性。此外，我们总结了调节 TAp63 和 ΔNp63 同工型的信号级联及其干性调节中的下游途径。© 2023。作者。

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an indispensable factor for their biological activities during epithelial development. The diversity of p63 isoforms expressed in distinct tissues allows this transcription factor to have a wide array of effects. p63 coordinates the transcription of genes involved in cell survival, stem cell self-renewal, migration, differentiation, and epithelial-to-mesenchymal transition. Through the regulation of these biological processes, p63 contributes to, not only normal epithelial development, but also epithelium-derived cancer pathogenesis. In this review, we provide an overview of the role of p63 in epithelial stemness regulation, including self-renewal, differentiation, proliferation, and senescence. We describe the differential expression of TAp63 and ΔNp63 isoforms and their distinct functional activities in normal epithelial tissues and in epithelium-derived tumors. Furthermore, we summarize the signaling cascades modulating the TAp63 and ΔNp63 isoforms as well as their downstream pathways in stemness regulation.© 2023. The Author(s).