大多数与癌症相关的死亡是由转移引起的，转移通常发生在多个器官部位，包括大脑、骨骼和肺部。尽管长期以来的观察表明癌症的扩散不是随机的，但我们对特定器官转移扩散机制的理解仍然有限。然而，新陈代谢最近已成为转移的重要因素。氨基酸是癌细胞及其代谢的重要营养来源，可以为生物合成途径提供燃料，从而促进细胞存活和肿瘤扩张，同时还能抵御氧化应激。与原发肿瘤相比，每个常见的转移部位都表现出截然不同的营养成分和环境压力源，因此癌细胞在定植和生长过程中需要在新环境中代谢旺盛。本综述旨在总结当前有关支持常见继发部位转移的氨基酸代谢途径的文献，包括对免疫反应的影响。了解氨基酸在次要器官部位的作用可能为治疗性抑制癌症转移提供机会。© 2023。这是美国政府的作品，在美国不受版权保护；外国版权保护可能适用。

Most cancer-related deaths are caused by the metastases, which commonly develop at multiple organ sites including the brain, bone, and lungs. Despite longstanding observations that the spread of cancer is not random, our understanding of the mechanisms that underlie metastatic spread to specific organs remains limited. However, metabolism has recently emerged as an important contributor to metastasis. Amino acids are a significant nutrient source to cancer cells and their metabolism which can serve to fuel biosynthetic pathways capable of facilitating cell survival and tumor expansion while also defending against oxidative stress. Compared to the primary tumor, each of the common metastatic sites exhibit vastly different nutrient compositions and environmental stressors, necessitating the need of cancer cells to metabolically thrive in their new environment during colonization and outgrowth. This review seeks to summarize the current literature on amino acid metabolism pathways that support metastasis to common secondary sites, including impacts on immune responses. Understanding the role of amino acids in secondary organ sites may offer opportunities for therapeutic inhibition of cancer metastasis.© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.