PI5P（磷脂酰肌醇-5-磷酸）的意外发现于 25 年前发表，当时 PIP5K II 型（磷酸肌醇-4-磷酸 5-激酶）实际上是一种 4-激酶，使用 PI5P 作为底物生成 PI (4,5)P2。因此，II型PIP5K更名为PI5P4K，或简称PIP4K，PI5P成为7种信号磷酸肌醇中最后一个被发现的。我们对 PI5P 的了解大部分来自于 PIP4K 的遗传学研究，因为 PI5P 合成途径、PI5P 下游靶标以及 PI5P 如何影响细胞功能在很大程度上仍然是个谜。然而，PI5P 和 PI5P 依赖性 PI(4,5)P2 合成显然与代谢稳态和癌症等疾病有关。在这里，我们回顾了过去 25 年的 PI5P 研究，特别强调了这种小信号脂质对人类健康的影响。版权所有 © 2023 Rameh 和 Blind。

The accidental discovery of PI5P (phosphatidylinositol-5-phosphate) was published 25 years ago, when PIP5K type II (phosphoinositide-4-phosphate 5-kinase) was shown to actually be a 4-kinase that uses PI5P as a substrate to generate PI(4,5)P2. Consequently, PIP5K type II was renamed to PI5P4K, or PIP4K for short, and PI5P became the last of the 7 signaling phosphoinositides to be discovered. Much of what we know about PI5P comes from genetic studies of PIP4K, as the pathways for PI5P synthesis, the downstream targets of PI5P and how PI5P affects cellular function all remain largely enigmatic. Nevertheless, PI5P and PI5P-dependent PI(4,5)P2 synthesis have been clearly implicated in metabolic homeostasis and in diseases such as cancer. Here, we review the past 25 years of PI5P research, with particular emphasis on the impact this small signaling lipid has on human health.Copyright © 2023 Rameh and Blind.