本研究调查了1999-2018年韩国市级8种主要癌症发病率的地区差异，并评估了2014-2018年期间是否存在癌症聚集热点。使用了韩国国家癌症发病率数据库。在市级按性别和地区计算 5 年 4 个时期和 8 种癌症类型的年龄标准化发病率。区域差异以绝对和相对衡量标准进行计算。使用全局 Moran's I 和基于邻近或距离的空间权重矩阵来检查聚类的可能性。在 20 年的研究期间，区域差异根据癌症类型和性别而变化。对于男性来说，胃癌、结肠癌、直肠癌、肺癌和肝癌的地区差异有所下降，甲状腺癌和前列腺癌的地区差异最近也有所下降，尽管总体发病率有所上升。对于女性来说，胃癌、结肠癌、直肠癌、肺癌、肝癌和宫颈癌的地区差异有所下降，尽管总体发病率有所上升，但甲状腺癌的发病率最近有所下降，乳腺癌的发病率稳步上升。 2014-2018年，乳腺癌（I，0.61；95% CI，0.53至0.70）在女性中表现出高概率的癌症集群，肝癌（I，0.48；95% CI，0.40至0.56）在女性中表现出高概率的癌症集群。男性癌症集群。在城市一级发现了在国家一级未发现的癌症发病率差异。这些可以为当地癌症政策的规划和实施提供重要方向。

This study investigated regional disparities in the incidence of 8 major cancers at the municipal level in South Korea during 1999-2018 and evaluated the presence or absence of hot spots of cancer clusters during 2014-2018.The Korea National Cancer Incidence Database was used. Age-standardized incidence rates were calculated by sex and region at the municipal level for 4 periods of 5 years and 8 cancer types. Regional disparities were calculated as both absolute and relative measures. The possibility of clusters was examined using global Moran's I with a spatial weight matrix based on adjacency or distance.Regional disparities varied depending on cancer type and sex during the 20-year study period. For men, the regional disparities of stomach, colon and rectum, lung, and liver cancer declined, and those of thyroid and prostate cancer recently decreased, despite an overall increasing incidence. For women, regional disparities in stomach, colon and rectum, lung, liver, and cervical cancer declined, that of thyroid cancer recently decreased, despite an overall increasing incidence, and that of breast cancer steadily increased. In 2014-2018, breast cancer (I, 0.61; 95% CI, 0.53 to 0.70) showed a high probability of cancer clusters in women, and liver cancer (I, 0.48; 95% CI, 0.40 to 0.56) showed a high probability of cancer clusters in men.Disparities in cancer incidence that were not seen at the national level were discovered at the municipal level. These.could provide important directions for planning and implementing local cancer policies.