黄曲霉毒素 B1 (AFB1) 是动物饲料和人类食品中发现的一种真菌代谢物。它是黄曲霉毒素中毒性最强、致癌性最强的一种，被列为第一类致癌物。饮食中接触 AFB1 和感染慢性乙型肝炎病毒 (HBV) 是肝细胞癌 (HCC) 的两个主要危险因素。这两个主要风险因素增加了两种药物之间产生协同作用的可能性。这篇综述提出了 AFB1 和 HBV 之间相互作用的一些协同分子机制，可加速或放大 HCC 的影响。 HBV的HBx病毒蛋白是HBV的主要病毒蛋白之一，具有许多与HCC有关的致癌特性。 AFB1 被 CYP450 代谢后，会变成 AFB1-exo-8,9-环氧化物 (AFBO)，这是一种剧毒化合物，可以在 DNA 序列中形成加合物并诱导突变。考虑到 HBV 和 AFB1 之间可能存在协同作用，最好同时治疗两种药物以降低 HCC 风险。版权所有 © 2023。由 Elsevier B.V. 出版。

Aflatoxin B1 (AFB1) is a fungal metabolite found in animal feeds and human foods. It is one of the most toxic and carcinogenic of aflatoxins and is classified as a Group 1 carcinogen. Dietary exposure to AFB1 and infection with chronic Hepatitis B Virus (HBV) make up two of the major risk factors for hepatocellular carcinoma (HCC). These two major risk factors raise the probability of synergism between the two agents. This review proposes some collaborative molecular mechanisms underlying the interaction between AFB1 and HBV in accelerating or magnifying the effects of HCC. The HBx viral protein of HBV is one of the main viral proteins of HBV and has many carcinogenic qualities that are involved with HCC. AFB1, when metabolized by CYP450, becomes AFB1-exo-8,9-epoxide (AFBO), an extremely toxic compound that can form adducts in DNA sequences and induce mutations. With possible synergisms that exist between HBV and AFB1 in mind, it is best to treat both agents simultaneously to reduce the risk by HCC.Copyright © 2023. Published by Elsevier B.V.