适应性抗癌免疫的线粒体检查点。
A mitochondrial checkpoint to adaptive anticancer immunity.
发表日期：2023
作者：
Oliver Kepp, Peng Liu, Guido Kroemer, Lorenzo Galluzzi
来源：
OncoImmunology
摘要：
BCL2 能够强有力地保持线粒体完整性，从而抑制多种细胞类型中的先天免疫信号传导和细胞凋亡。在此，我们对最近的数据进行评论，这些数据表明 BCL2 还限制树突状细胞引发适应性免疫反应的能力，为线粒体免疫检查点的通用免疫抑制功能提供支持。© 2023 作者。经泰勒许可出版
BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint.© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.