癌细胞异质性是治疗失败和治疗后复发的关键因素。针对化疗耐药和复发的细胞亚群似乎是改善癌症患者治疗结果的一种有吸引力的方法。然而，由于肿瘤细胞亚群的复杂性和不完整的表征，这仍然具有挑战性。表现出干性相关特征（例如自我更新和化学抗性）的细胞的异质性加剧了这种复杂性。 Notch 信号传导是结直肠癌 (CRC) 中癌症干细胞 (CSC) 特征的已知调节因子，尽管其异质信号传导对 CRC 细胞干性的影响才刚刚出现。在这篇综述中，我们讨论了 Notch 配体-受体特异性如何有助于调节 CRC 中的干性、自我更新、化疗耐药性和癌症干细胞异质性。版权所有 © 2023 Brisset、Mehlen、Meurette 和 Hollande。

Cancer cell heterogeneity is a key contributor to therapeutic failure and post-treatment recurrence. Targeting cell subpopulations responsible for chemoresistance and recurrence seems to be an attractive approach to improve treatment outcome in cancer patients. However, this remains challenging due to the complexity and incomplete characterization of tumor cell subpopulations. The heterogeneity of cells exhibiting stemness-related features, such as self-renewal and chemoresistance, fuels this complexity. Notch signaling is a known regulator of cancer stem cell (CSC) features in colorectal cancer (CRC), though the effects of its heterogenous signaling on CRC cell stemness are only just emerging. In this review, we discuss how Notch ligand-receptor specificity contributes to regulating stemness, self-renewal, chemoresistance and cancer stem cells heterogeneity in CRC.Copyright © 2023 Brisset, Mehlen, Meurette and Hollande.