甲状腺全切除术（TT）和半甲状腺切除术（HT）是治疗低危分化型甲状腺癌（DTC）可接受的手术选择。虽然之前的数据表明，无论初始手术治疗如何，无病生存率和疾病特异性生存率相似，但手术范围对健康相关生活质量 (HRQOL) 的影响尚不清楚。本系统综述旨在检查 TT 与 HT 后低风险 DTC 幸存者的 HRQOL。对 PubMed、CINAHL、Cochrane、PsycINFO 和 Scopus 数据库进行检索，以确定 2011 年 1 月 1 日至 2022 年 12 月 31 日期间发表的研究，这些研究主要评估接受开放甲状腺手术的低风险 DTC 患者的 HRQOL。 Covidence™ 软件用于应用纳入标准，并使用经过验证的仪器来评估研究质量。纳入了 1,402 项已确定研究中的 16 项：5 项前瞻性队列研究和 11 项回顾性队列研究。大多数纳入的研究质量良好 (n=14)，并且来自亚洲和中东 (n=11)。总体而言，6 项研究得出结论，HT 比 TT 带来更好的 HRQOL，2 项研究得出结论，与中央颈清扫术 (CND) 的 TT 相比，HT 仅导致更好的 HRQOL，2 项研究得出结论 HT 导致更好的短期 HRQOL，但在术后 6 个月消失。所有研究发现，HT 治疗后，HRQOL 领域得到最持续的改善，包括身体健康、心理/情绪和社会功能。超过一项研究发现与 HRQOL 相关的因素包括年龄、阶段和婚姻状况。HT 和 TT 后 HRQOL 的差异往往有利于 HT，特别是在手术后 6 个月内测量或与 TT 和 CND 相比时。需要额外的前瞻性和理想随机数据来充分确定手术范围对低危甲状腺癌患者 HRQOL 的影响。

Total (TT) and hemi-thyroidectomy (HT) are acceptable surgical options for the treatment of low-risk differentiated thyroid cancer (DTC). While previous data suggest similar disease-free and disease-specific survival regardless of initial surgical treatment, the effect of the extent of surgery on health-related quality of life (HRQOL) is less clear. This systematic review aimed to examine HRQOL in low-risk DTC survivors after TT compared to HT.A search of PubMed, CINAHL, Cochrane, PsycINFO, and Scopus databases was conducted to identify studies published between January 1, 2011 and December 31, 2022 that assessed HRQOL predominantly in patients with low-risk DTC who underwent open thyroid surgery. Covidence™ software was used to apply inclusion criteria, and a validated instrument was used to assess study quality.Sixteen of 1,402 identified studies were included: 5 prospective and 11 retrospective cohort studies. The majority of included studies were of good quality (n=14) and were from Asia and the Middle East (n=11). Overall, 6 studies concluded that HT led to better HRQOL than TT, 2 concluded HT only resulted in better HRQOL compared to TT with central neck dissection (CND), and 2 concluded HT resulted in better short-term HRQOL that dissipated by six months postoperatively. The HRQOL domains found across all studies to be most consistently improved after HT included physical health, psychological/emotional, and social function. Factors found to be associated with HRQOL in more than one study included age, stage, and marital status.Differences in HRQOL after HT and TT tended to favor HT particularly when measured <6 months after surgery or when compared to TT with CND. Additional prospective and ideally randomized data are needed to fully determine the impact of the extent of surgery on HRQOL in patients with low-risk thyroid cancer.