低骨骼肌质量正在成为癌症患者的不良预测和预后因素。目前临床实践中尚未使用该参数作为术后并发症的危险因素。这项荟萃分析旨在评估放射学标准定义的低骨骼肌质量与头颈癌患者重建显微手术后并发症的关系。使用 PubMed、EMBASE 数据库和手动检索对文章进行系统评价。选择评估低骨骼肌质量及其对接受游离皮瓣手术的头颈癌患者术后并发症的影响的文章。通过提取比值比 (OR) 和 95% 置信区间 (CI) 来计算术后结果数据的汇总估计值。检索策略返回 6 项符合纳入标准的研究。总共分析了 1082 名患者。研究之间骨骼肌质量低的患病率范围为 24.6% 至 61.5%。荟萃分析显示，术后并发症的 OR 为 2.42（95% CI 1.53-3.32，p = 0.00）。因此，该研究得出结论，骨骼肌质量是头颈癌重建手术患者术后并发症的独立危险因素。这主张在术前管理中实施低骨骼肌筛查，以优化手术决策。版权所有 © 2023。由 Elsevier Ltd 出版。

Low skeletal muscle mass is emerging as an adverse predictive and prognostic factor in cancer patients. The use of this parameter as a risk factor for complications after surgery is not currently used in clinical practice. This meta-analysis aims to assess the association of low skeletal muscle mass defined by radiological criteria and complications after reconstructive microsurgery in head and neck cancer patients. A systematic review for articles was performed using the PubMed, EMBASE database and by manual search. Articles that assessed low skeletal muscle mass and its impact on postoperative complications in head and neck cancer patients undergoing free flap surgery were selected. Pooled estimates of postoperative outcome data were calculated by extracting the odds ratio (OR) and 95% confidence interval (CI). The search strategy returned with 6 studies meeting the inclusion criteria. A total of 1082 patients were analyzed. The prevalence of low skeletal muscle mass between studies ranged from 24.6% to 61.5%. The meta-analysis showed an OR for complications after surgery of 2.42 (95% CI 1.53-3.32, p = 0.00). The study therefore concludes that skeletal muscle mass is an independent risk factor for postoperative complications in head and neck cancer reconstructive surgery patients. This argues for implementing screening for low skeletal muscle in preoperative management to optimize surgical decision making.Copyright © 2023. Published by Elsevier Ltd.