癌症铠甲的新缝隙：通过选择性 PP5 抑制释放细胞死亡。
A new chink in cancer's armor: Unleashing cell death by selective PP5 inhibition.
发表日期：2023 Oct 19
作者：
Patricija van Oosten-Hawle
来源：
Cell Chemical Biology
摘要：
丝氨酸/苏氨酸蛋白磷酸酶在多种癌症的存活和增殖中发挥着重要作用。在本期《细胞化学生物学》中，Ahanin 等人1 证明蛋白磷酸酶 5 (PP5) 独立于 Hsp90 使细胞死亡效应蛋白 FADD 去磷酸化和失活，并且他们确定了选择性 PP5 抑制剂作为肾癌的新治疗策略。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
Serine/threonine protein phosphatases play a significant role in the survival and propagation of multiple cancers. In this issue of Cell Chemical Biology, Ahanin et al.1 demonstrate that protein phosphatase 5 (PP5) dephosphorylates and inactivates the cell death effector protein FADD independently of Hsp90, and they identify a selective PP5 inhibitor as a new therapeutic strategy for renal cancer.Copyright © 2023 Elsevier Ltd. All rights reserved.