使 CAR T 细胞看不见正常的造血作用。
Making normal hematopoiesis invisible to CAR T cells.
发表日期：2023 Oct 18
作者：
Miriam Y Kim
来源：
Trends in Cancer
摘要：
Casirati 等人最近的两项研究。和 Wellhausen 等人报道，通过改变靶蛋白中的单个氨基酸来消除 CAR 结合，而不损害蛋白质，对正常造血干细胞和祖细胞 (HSPC) 进行基因改造，使其能够抵抗嵌合抗原受体 (CAR)-T 细胞功能。这样可以选择性地靶向癌细胞，而不伤害正常造血细胞。版权所有 © 2023 Elsevier Inc. 保留所有权利。
Two recent studies, by Casirati et al. and Wellhausen et al., report genetically engineering normal hematopoietic stem and progenitor cells (HSPCs) to be resistant to chimeric antigen receptor (CAR)-T cells, by changing a single amino acid in the target protein that abrogates CAR binding, without compromising protein function. This allows for selective targeting of cancer cells without harming normal hematopoietic cells.Copyright © 2023 Elsevier Inc. All rights reserved.