在实体瘤发展的早期，抗原出现在肿瘤引流淋巴结（tdLN）中，这是建立免疫监视所必需的过程。最近的证据表明，tdLN 可以促进全身性肿瘤特异性 T 细胞反应，这可能会阻止癌症进展并促进未来对免疫治疗的反应。然而，这些保护性反应会受到进行性功能障碍的影响，而淋巴结（LN）转移会加剧这种功能障碍。我们讨论了新兴的临床前和临床文献，这些文献表明 tdLN 是系统免疫的重要储存库，可以增强免疫监视。我们还讨论了淋巴结转移的影响，并认为更好地了解淋巴结转移与全身免疫之间的关系对于指导免疫治疗时代的区域疾病管理是必要的。版权所有 © 2023 作者。由爱思唯尔公司出版。保留所有权利。

Early in solid tumor development, antigens are presented in tumor-draining lymph nodes (tdLNs), a process that is necessary to set up immune surveillance. Recent evidence indicates that tdLNs fuel systemic tumor-specific T cell responses which may halt cancer progression and facilitate future responses to immunotherapy. These protective responses, however, are subject to progressive dysfunction exacerbated by lymph node (LN) metastasis. We discuss emerging preclinical and clinical literature indicating that the tdLN is a crucial reservoir for systemic immunity that can potentiate immune surveillance. We also discuss the impact of LN metastasis and argue that a better understanding of the relationship between LN metastasis and systemic immunity will be necessary to direct regional disease management in the era of immunotherapy.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.