来自肿瘤学物理科学的证据越来越多地表明，生物物理肿瘤微环境和基因调控之间的相互作用对肿瘤进展具有重大影响。特别是，肿瘤细胞和相关的基质细胞不仅改变其自身的细胞骨架和物理特性，而且还重塑具有异常物理特性的微环境。总之，肿瘤组织及其成分的这些改变的力学组学从根本上改变了肿瘤和基质细胞中的力学转导范式，并激活肿瘤微环境内的致癌信号传导以促进肿瘤进展。然而，目前关于肿瘤生物物理学的发现是有限的、分散的，并且在多种情况下往往是矛盾的。仍然缺乏对生物物理线索如何影响肿瘤病理生理学的系统理解。这篇综述讨论了多尺度力学生物学和尖端技术在肿瘤生物物理学方面最新的不同流派的发现。这些发现范围从分子和细胞到整个组织水平，并以机械转导和致癌信号传导之间的功能串扰为特征。我们强调这些异常物理变化作为癌症机械医学新治疗靶点的潜力。该框架协调了该领域的相反意见，为未来的癌症研究提出了新的方向，并概念化了新的机械医学景观，以克服传统癌症诊断和治疗的固有缺点。© 2023。作者。

Evidence from physical sciences in oncology increasingly suggests that the interplay between the biophysical tumor microenvironment and genetic regulation has significant impact on tumor progression. Especially, tumor cells and the associated stromal cells not only alter their own cytoskeleton and physical properties but also remodel the microenvironment with anomalous physical properties. Together, these altered mechano-omics of tumor tissues and their constituents fundamentally shift the mechanotransduction paradigms in tumorous and stromal cells and activate oncogenic signaling within the neoplastic niche to facilitate tumor progression. However, current findings on tumor biophysics are limited, scattered, and often contradictory in multiple contexts. Systematic understanding of how biophysical cues influence tumor pathophysiology is still lacking. This review discusses recent different schools of findings in tumor biophysics that have arisen from multi-scale mechanobiology and the cutting-edge technologies. These findings range from the molecular and cellular to the whole tissue level and feature functional crosstalk between mechanotransduction and oncogenic signaling. We highlight the potential of these anomalous physical alterations as new therapeutic targets for cancer mechanomedicine. This framework reconciles opposing opinions in the field, proposes new directions for future cancer research, and conceptualizes novel mechanomedicine landscape to overcome the inherent shortcomings of conventional cancer diagnosis and therapies.© 2023. The Author(s).