关于身体虚弱在癌症相关结果中的作用的证据有限。我们旨在研究虚弱与癌症发病率和死亡风险之间的关系。这项前瞻性研究纳入了来自英国生物银行的 348,144 名基线时未患癌症的参与者。虚弱表型（非虚弱、虚弱前和虚弱）由 5 个组成部分构成：体重减轻、疲惫、体力活动低、步态速度慢和握力低。结果是总体癌症和特定城市癌症的发病率和死亡率。 Cox 比例风险回归用于估计虚弱表型与癌症发病率和死亡风险的关联。在中位 12.0 年的随访期间，总共记录了 43,304 例癌症病例和 10,152 例癌症死亡病例。对于整体癌症而言，与非衰弱状态相比，衰弱前期的发病风险增加了4%，衰弱的发病风险增加了11%，衰弱前期的死亡风险增加了11%，衰弱的死亡风险增加了39%。虚弱表型还与某些特定部位癌症（包括肝癌和肺癌）的较高发病率和死亡率风险呈剂量依赖性相关，且存在显着的性别差异。我们观察到虚弱表型和吸烟与总体癌症发病率和死亡风险之间存在协同关联。虚弱表型以逐步方式或在个别类别内显着导致总体和某些特定部位癌症发病率和死亡率的较高风险。未来的研究有必要强调识别、管理和预防整个人群的虚弱，并补充以生活方式为目标的干预措施，例如戒烟。版权所有 © 2023。由爱思唯尔公司出版。

Evidence regarding the role of physical frailty in cancer-related outcomes is limited. We aimed to examine the association of frailty with cancer incidence and mortality risk.This prospective study included 348,144 participants free of cancer at baseline from the UK Biobank. Frailty phenotypes (non-frail, pre-frail, and frail) were constructed from 5 components: weight loss, exhaustion, low physical activity, slow gait speed, and low grip strength. The outcome was incidence and mortality of overall and cite-specific cancers. Cox proportional hazard regression was used to estimate the association of frailty phenotypes with cancer incidence and mortality risk.A total of 43,304 incident cancer cases and 10,152 cancer deaths were documented during a median of 12.0 years of follow-up. For overall cancer, compared with non-frailty, the incidence risk increased by 4% for pre-frailty and 11% for frailty, and the mortality risk increased by 11% for pre-frailty and 39% for frailty. Frailty phenotypes were also dose-dependently associated with a higher risk of incidence and mortality of some site-specific cancers (including liver and lung), with significant sex differences. We observed a synergetic association of frailty phenotypes and smoking with overall cancer incidence and mortality risk.Frailty phenotypes contributed significantly to a higher risk of overall and some site-specific cancers incidence and mortality in a stepwise manner or within individual categories. Future studies are warranted to emphasize the identification, management and prevention of frailty in the whole population and complements of lifestyle-targeted interventions such as quitting smoking.Copyright © 2023. Published by Elsevier Inc.