研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

从人群健康角度看基底细胞癌的分子遗传学[J].

[The molecular genetic aspects of basal cell carcinoma from the position of population health preservation].

发表日期:2023 Sep
作者: R U Khabriev, R N Sadykova, E N Mingazova, J A Bespyatykh
来源: GENES & DEVELOPMENT

摘要:

探索癌症发生的分子遗传学机制、各种肿瘤疾病的遗传因素,包括基底细胞癌(最常见的皮肤癌类型)对于公共卫生的目标策略尤其实际且重要。基底细胞癌的诊断基于复杂的临床、放射学和基因检查数据。与基底细胞癌相关的基因体细胞或遗传性突变领域的进一步研究,包括Patched 1 (PTCH1)、Patched 2 (PTCH2)、Smoothed (SMO)仍然是热门话题。基底细胞癌的初级预防策略、初级卫生保健层面治疗决策复杂问题的讨论、全科医生培训课程和指南的制定以及基底细胞癌有效早期诊断和综合护理的跨学科建议待建议。
The exploration of molecular genetic mechanisms that underlie carcinogenesis, hereditary factors of various oncological diseases, including basal cell carcinoma, the most common type of skin cancer is especially actual and significant for target strategies of public health. The diagnosis of basal cell carcinoma is based on complex clinical, radiologic and genetic examination data. The further research in the field of somatic or hereditary mutations in genes associated with basal cell carcinoma, including Patched 1 (PTCH1), Patched 2 (PTCH2), Smoothed (SMO) continue to be topical. The strategies of primary prevention of basal cell carcinoma, discussions of complex issues of decision-making concerning treatment at primary health care level, training courses and development of guidelines for general practitioners and interdisciplinary recommendations for effective early diagnosis and comprehensive care of basal cell carcinoma are to be suggested.