目的：分析文献来源，评估使用天然自身白细胞皮内免疫方法治疗不同疾病的可能性，探讨该技术在临床实践中的使用领域、功效和便利性。材料和方法：文献来源分析结论：文献综述中考虑了使用天然自身白细胞皮内免疫方法治疗各种疾病的可能性。自体白细胞皮内免疫是个体化医疗的方法之一。该方法的应用导致免疫系统状况正常化以及自身免疫和炎症过程的抑制。它还可以减少促炎细胞因子的合成，并增强多种病毒感染中的细胞抗病毒免疫力。特别地，已证明该方法减少了冷球蛋白的合成、抗甲状腺抗体的形成、使肿瘤坏死因子α的水平正常化、以及减少了慢性肝炎的肝外表现并提高了患者抗病毒治疗的有效性。乙型病毒性肝炎。考虑到用天然自身白细胞免疫没有禁忌症，因此可以用于许多疾病。

The aim: Analyzing literature sources, to assess possibilities of using the method of intradermal immunization with native autoleukocytes to treat different diseases, to investigate the areas of usage, efficacy and expediency of the technique in clinical practice.Materials and methods: Analysis of literature sources associated with intradermal immunization with native autoleukocytes.Conclusions: The possibilities of using the method of intradermal immunization with native autoleukocytes in the treatment of various diseases are consid¬ered in the literature review. Intradermal immunization with autoleukocytes is one of the methods of personalized medicine. The application of the method results in normalization of the immune system condition as well as suppression of autoimmune and inflammatory processes. It also reduces the synthesis of pro-inflammatory cytokines and strengthens cellular antiviral immunity in a number of viral infections. It is proved, in particular, that the method reduces the synthesis of cryoglobulins, the formation of antithyroid antibodies, normalizes the level of tumor necrosis factor alpha, as well as reduces extrahepatic manifestations of chronic hepatitis and increases the effectiveness of antiviral therapy in patients with viral hepatitis B. Considering that immunization with native autoleukocytes has no contraindications, it can be used in many diseases.