随着免疫检查点抑制剂在癌症治疗中的发展，肿瘤微环境作为免疫治疗的关键部分引起了许多研究人员的关注。调节性T细胞、髓源性抑制细胞和肿瘤相关巨噬细胞等免疫抑制细胞在多发性骨髓瘤骨髓微环境中的抗肿瘤免疫调节中发挥着重要作用，此外还降低了肿瘤细胞的免疫原性和增加了免疫检查点分子。这些细胞被肿瘤细胞或其周围环境释放的多种化学物质激活，并抑制树突状、肿瘤特异性细胞毒性 T、NK 和 NKT 细胞。多发性骨髓瘤细胞利用免疫抑制作用来逃避患者的免疫监视系统。未来，我们希望更好地了解这些免疫抑制细胞，从而进一步改进免疫疗法。

With the development of immune checkpoint inhibitors in cancer therapy, tumor microenvironments have attracted the attention of many researchers as a critical compartment of immune therapies. Immune suppressive cells such as regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages play important roles in regulating anti-tumor immunity in the bone marrow microenvironment in multiple myeloma, in addition to decreased immunogenicity of tumor cells and increased expression of immune checkpoint molecules. These cells are activated by numerous chemicals released by tumor cells or their surroundings, and they suppress dendritic, tumor-specific cytotoxic T, NK, and NKT cells. Multiple myeloma cells use immunological suppressive effects to escape the patients' immune surveillance system. In the future, we hope a better understanding of these immune suppressive cells leads to further improvements in immune therapies.