初级纤毛是细胞器，由微管骨架组成，微管骨架被充满细胞信号受体的膜包围。许多研究表明，初级纤毛是细胞天线，作为信号中枢，其组装和分解在整个细胞周期中受到动态调节，在调节细胞稳态中发挥着重要作用。原发纤毛动力学的异常控制会导致许多称为纤毛病的遗传性疾病，并且与肿瘤发生密切相关。尽管没有明显的治疗方法，但抗癌药物耐药性是化疗失败的主要原因。最近发现的抗癌药物耐药性与初级纤毛动力学之间的关系使得初级纤毛成为克服抗癌药物耐药性的重要靶亚细胞器。因此，对原发性纤毛动力学的研究可能为克服抗癌耐药性提供新的策略，这是迫切需要的。本综述旨在总结初级纤毛与抗癌药物耐药性相关性的研究，以及未来利用初级纤毛动力学克服抗癌药物耐药性研究的可能性。版权所有 © 2023 Lee。

Primary cilia are cellular organelles that consist of a microtubule skeleton surrounded by a membrane filled with cell signaling receptors. Many studies have shown that primary cilia are cellular antennas, which serve as signaling hubs and their assembly and disassembly are dynamically regulated throughout the cell cycle, playing an important role in regulating cellular homeostasis. Aberrant control of primary cilia dynamics causes a number of genetic disorders known as ciliopathies and is closely associated with tumorigenesis. Anticancer drug resistance is a primary cause of chemotherapy failure, although there is no apparent remedy. The recent identification of a relationship between anticancer drug resistance and primary ciliary dynamics has made primary cilia an important target subcellular organelle for overcoming anticancer drug resistance. Therefore, the research on primary ciliary dynamics may provide new strategies to overcome anticancer drug resistance, which is urgently needed. This review aims to summarize research on the relevance of primary cilia and anticancer drug resistance, as well as future possibilities for research on overcoming anticancer drug resistance utilizing primary cilia dynamics.Copyright © 2023 Lee.