类天疱疮组包括多种大疱性皮肤病，其具有针对基底膜区不同成分的自身抗体，导致表皮下脱离和临床特征性紧张性水疱、糜烂、荨麻疹性红斑和瘙痒。除了最常见的具有 BP180 抗体的大疱性类天疱疮主要见于老年患者外，该疾病也可能出现在其他年龄和不同的致病条件下。这里展示了 4 例年轻病例（3 个月、25 岁、34 岁和 46 岁），且与疫苗接种、怀孕或转移性癌症有关。尽管在所有病例中都发现了抗 BP180，但在任何病例中都可能发现不同的致病背景，从而导致特征性的临床表现，但需要专门调整的治疗方法。版权所有 © 2023 Rechtien、Solfrank、Foerster、Berking 和 Sticherling。

The pemphigoid group comprises a number of bullous skin diseases with autoantibodies against different constituents of the basement membrane zone that result in subepidermal detachment and clinically characteristic tense blisters, erosions, urticarial erythema, and itching. Apart from the most frequent type of bullous pemphigoid with antibodies against BP180, which is found predominantly in elderly patients, the disease may present at other ages and different pathogenic conditions. Here, four cases are presented of young age (3 months and 25, 34, and 46 years) and in association with vaccination, pregnancy, or metastatic cancer. Though anti-BP180 was found in all cases, a different pathogenic background may be found in any of them, resulting in characteristic clinical manifestation, yet demanding specifically adapted therapeutic approaches.Copyright © 2023 Rechtien, Sollfrank, Foerster, Berking and Sticherling.