线粒体抗病毒信号蛋白（MAVS）是线粒体外膜上的关键先天免疫接头，在病毒感染的免疫信号转导反应中充当开关。一些研究报道，MAVS 在病毒感染期间介导 NF-κB 和 I 型干扰素信号传导，并且也是最佳 NLRP3 炎性体活性所必需的。最近的研究报道MAVS与多种癌症、系统性红斑狼疮、肾脏疾病和心血管疾病有关。在此，我们总结了肾脏疾病的结构、激活、病理生理作用和基于 MAVS 的疗法。这篇综述对 MAVS 在肾脏疾病发病机制中的作用和治疗潜力提供了新的见解。版权所有 © 2023 Wu、Pei、Long、Chen、Jia 和 Xia。

Mitochondrial antiviral signaling protein (MAVS) is a key innate immune adaptor on the outer mitochondrial membrane that acts as a switch in the immune signal transduction response to viral infections. Some studies have reported that MAVS mediates NF-κB and type I interferon signaling during viral infection and is also required for optimal NLRP3 inflammasome activity. Recent studies have reported that MAVS is involved in various cancers, systemic lupus erythematosus, kidney diseases, and cardiovascular diseases. Herein, we summarize the structure, activation, pathophysiological roles, and MAVS-based therapies for renal diseases. This review provides novel insights into MAVS's role and therapeutic potential in the pathogenesis of renal diseases.Copyright © 2023 Wu, Pei, Long, Chen, Jia and Xia.