迄今为止，乳腺癌仍然是全球女性癌症相关死亡的主要原因。尽管乳腺癌的治疗方法和方案不断完善，但由于疾病复杂的异质性、多器官转移、化疗和放疗耐药，患者的长期预后仍然不容乐观。 ncRNA作为一类新发现的非编码RNA，在多种癌症中发挥着重要作用。尤其是在乳腺癌中，lncRNA受到了广泛关注，并已被证实可以通过多种途径调节癌症进展。同时，包括DNA甲基化、RNA甲基化和组蛋白修饰在内的表观遗传修饰的研究近年来迅速发展，极大地促进了人们对非编码RNA在乳腺癌中重要作用的重视。在这篇综述中，我们仔细、全面地描述了几类主要的表观遗传修饰和 ncRNA 之间的相互作用，以及它们不同的后续生物学效应，并讨论了它们在实际临床应用中的潜力。版权所有 © 2023 Xie, Gan, Xu, Wang and裴。

Up till the present moment, breast cancer is still the leading cause of cancer-related death in women worldwide. Although the treatment methods and protocols for breast cancer are constantly improving, the long-term prognosis of patients is still not optimistic due to the complex heterogeneity of the disease, multi-organ metastasis, chemotherapy and radiotherapy resistance. As a newly discovered class of non-coding RNAs, ncRNAs play an important role in various cancers. Especially in breast cancer, lncRNAs have received extensive attention and have been confirmed to regulate cancer progression through a variety of pathways. Meanwhile, the study of epigenetic modification, including DNA methylation, RNA methylation and histone modification, has developed rapidly in recent years, which has greatly promoted the attention to the important role of non-coding RNAs in breast cancer. In this review, we carefully and comprehensively describe the interactions between several major classes of epigenetic modifications and ncRNAs, as well as their different subsequent biological effects, and discuss their potential for practical clinical applications.Copyright © 2023 Xie, Gan, Xue, Wang and Pei.