异基因造血干细胞移植（allo-HSCT）在世界范围内进行，用于治疗血癌和其他危及生命的血液疾病。由于成功的移植需要 HLA 相容的供体，世界范围内已经建立了无关的供体中心和登记处，为没有家庭匹配的患者寻找供体。在大型捐助登记处，少数族裔的代表性不足。当捐赠者和患者具有相同的种族背景时，匹配概率更高，因此需要通过在新地区招募捐赠者来增加全球捐赠者库的多样性。在这里，我们报告了第一个无关干细胞捐献中心在智利的建立和第一个 5 年的运营，智利是南美洲的一个高收入国家，人口超过 1900 万。我们采用了在线和现场捐献者招募做法通过患者呼吁和公司、大学、武装部队和公共服务部门的捐助活动。确认打字后，捐献者接受医疗检查并获准捐献。我们在 5 年内招募了近 170,000 名捐献者。收到了 1,488 份确认打字和捐献者可用性检查的请求，其中 333 份进行了医疗检查，从而收集了 194 份干细胞。产品销往智利（48.5%）和国外。即使 COVID-19 大流行对我们的活动提出了挑战，招募和运送干细胞产品的捐赠者数量仍然保持稳定。在智利，中心成立后，无关供体移植活动从 2016-2018 年的 16 例增加到 2019-2021 年的 124 例，增加了近 8 倍，主要针对儿科患者。我们估计 49.6% 的智利患者会在全球 DKMS 供体库中找到至少一名匹配的无关供体。在智利建立 DKMS 供体中心显着增加了智利患者的供体可用性，并有助于增加无关供体干细胞移植活动.版权所有 © 2023 Barriga、Solloch、Giani、Palma、Wietstruck、Sarmiento、Carvallo、Mosso、Ramirez、Sanchez、Rojas、Alfaro、Saldaña、Ende、Flaig、Pattillo 和 Schmidt。

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed worldwide to treat blood cancer and other life-threatening blood disorders. As successful transplantation requires an HLA-compatible donor, unrelated donor centers and registries have been established worldwide to identify donors for patients without a family match. Ethnic minorities are underrepresented in large donor registries. Matching probabilities are higher when donors and patients share the same ethnic background, making it desirable to increase the diversity of the global donor pool by recruiting donors in new regions. Here, we report the establishment and the first 5 years of operation of the first unrelated stem cell donor center in Chile, a high-income country in South America with a population of over 19 million.We used online and in-person donor recruitment practices through patient appeals and donor drives in companies, universities, the armed forces, and public services. After confirmatory typing donors were subjected to medical work-up and cleared for donation.We recruited almost 170,000 donors in 5 years. There were 1,488 requests received for confirmatory typing and donor availability checks, of which 333 resulted in medical work-up, leading to 194 stem cell collections. Products were shipped to Chile (48.5%) and abroad. Even when the COVID-19 pandemic challenged our activities, the number of donors recruited and shipped stem cell products remained steady. In Chile there was an almost 8-fold increase in unrelated donor transplantation activity from 16 procedures in 2016-2018 to 124 procedures in 2019-2021, mainly for pediatric patients following the center's establishment. We estimate that 49.6% of Chilean patients would find at least one matched unrelated donor in the global DKMS donor pool.Establishing a DKMS donor center in Chile has significantly increased donor availability for Chilean patients and contributed to an increase of unrelated donor stem cell transplant activity.Copyright © 2023 Barriga, Solloch, Giani, Palma, Wietstruck, Sarmiento, Carvallo, Mosso, Ramirez, Sanchez, Rojas, Alfaro, Saldaña, Ende, Flaig, Pattillo and Schmidt.