由特化上皮细胞组成的屏障表面将宿主机体与外界环境分隔开来，对于维持正常的肠道生理和免疫稳态至关重要。探讨炎症性肠病（IBD）肠道屏障研究的发展趋势和研究热点。与 IBD 肠道屏障相关的信息来自 Web of Science 核心合集数据库。使用 VOSviewer、CiteSpace 和 R 软件进行文献计量分析和可视化。共识别出 2002 年至 2022 年间发表的 4482 篇文章。美国在肠道屏障研究方面占据主导地位，而芝加哥大学是最活跃的机构。哈佛医学院的杰罗德是最多产、引用最多的作者。 《炎症性肠病》和《胃肠病学》杂志在该领域做出了重大贡献。检测IBD肠道屏障相关高频出现的关键词，包括核因子κB、肿瘤坏死因子-α、细胞凋亡、氧化应激和益生菌。其中，抗氧化剂、Akkermansia muciniphila、纳米颗粒、短链脂肪酸和细胞外囊泡近年来受到越来越多的研究兴趣。肠道屏障领域正在迅速发展，广泛合作。针对肠道微生物群和饮食代谢来调节肠道屏障已显示出有前景的应用前景并引起了广泛的兴趣。肠道屏障在IBD中的重要性逐渐被充分认识，为改善炎症和预后提供了新的治疗视角。©作者2023。百事登出版集团有限公司出版。保留所有权利。

Barrier surfaces composed of specialized epithelial cells separate the host body from the external environment, and are essential for maintaining proper intestinal physiologic and immune homeostasis.To explore the development trends and research hotspots of intestinal barrier research in inflammatory bowel disease (IBD).The publications related to the intestinal barrier in IBD were obtained from the Web of Science Core Collection database. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace and R software.A total of 4482 articles published between 2002 and 2022 were identified. The United States is dominant in intestinal barrier research, whereas the University of Chicago is the most active institution. Jerrold from Harvard Medical School was the most productive authors with the most citations. The journals Inflammatory Bowel Disease and Gastroenterology have made significant contributions in this field. The keywords appearing at high frequency related to the intestinal barrier in IBD were detected, including nuclear factor kappa B, tumor necrosis factor-α, apoptosis, oxidative stress and probiotics. Among them, antioxidants, Akkermansia muciniphila, nanoparticles, short-chain fatty acids and extracellular vesicles have received growing interest in recent research.The intestinal barrier field is developing rapidly with extensive cooperation. Targeting the gut microbiota and dietary metabolism to regulate the intestinal barrier has shown promising prospective applications and has generated broad interest. The importance of the intestinal barrier in IBD is gradually being fully recognized, providing a new therapeutic perspective for improving inflammation and prognosis.©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.