由原发性肿瘤衍生分子形成的转移前生态位（PMN）调节远处器官和组织，以进一步有利于肿瘤定植。靶向中性粒细胞治疗可以在早期预防肿瘤转移，这一点变得越来越重要。目前，人们对PMN的细胞和分子特征缺乏深入的了解。在这里，我们总结了目前中性粒细胞的细胞和分子特征的研究进展。我们强调，PMN 干预是一种早期预防肿瘤转移的潜在治疗策略，为未来的研究和临床应用提供了有前景的基础。© 2023 作者。约翰·威利出版的动物模型和实验医学

The premetastatic niches (PMN) formed by primary tumor-derived molecules regulate distant organs and tissues to further favor tumor colonization. Targeted PMN therapy may prevent tumor metastasis in the early stages, which is becoming increasingly important. At present, there is a lack of in-depth understanding of the cellular and molecular characteristics of the PMN. Here, we summarize current research advances on the cellular and molecular characteristics of the PMN. We emphasize that PMN intervention is a potential therapeutic strategy for early prevention of tumor metastasis, which provides a promising basis for future research and clinical application.© 2023 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.