乙型肝炎病毒 (HBV) 相关肝癌是全球第三大最常见的癌症相关死亡原因。人们对 HBV 诱导的肝癌的组织分子分析进行了不同的研究，包括表观遗传学（在不改变宿主脱氧核糖核酸的情况下控制基因表达的动态分子机制）、基因组学表征病毒基因组与宿主基因组的整合、蛋白质组学表征基因如何修饰糖蛋白组学发现不同的候选糖生物标志物并显示恶性肝细胞中的糖基化，代谢组学描述了乙型肝炎病毒在肝细胞永生化过程中如何损害各种代谢功能，外泌体描述了永生化肝细胞的分化和增殖特征，自噬发挥着作用在与 HBV 感染相关的肝癌发生中发挥作用。© 2023 作者。约翰·威利 (John Wiley) 发表的《医学病毒学评论》

Hepatitis B virus (HBV)-associated liver cancer is the third most prevalent cancer-related cause of death worldwide. Different studies have been done on the histomolecular analysis of HBV induced-liver cancer including epigenetics which are dynamic molecular mechanisms to control gene expression without altering the host deoxyribonucleic acid, genomics characterise the integration of the viral genome with host genome, proteomics characterise how gene modifies and results overexpression of proteins, glycoproteomics discover different glyco-biomarker candidates and show glycosylation in malignant hepatocytes, metabolomics characterise how HBV impairs a variety of metabolic functions during hepatocyte immortalisation, exosomes characterise immortalised liver cells in terms of their differentiation and proliferation, and autophagy plays a role in the development of hepatocarcinogenesis linked to HBV infection.© 2023 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.