探讨根治性膀胱切除术（RC）加改良单孔输尿管皮肤造口术（MSSCU）或回肠导管术（IC）患者术后体重指数（BMI）变化对术后生活质量（QOL）的影响。将患者分为两类根据不同的 BMI 变化模式进行分组：术后 BMI 水平升高且 BMI 临床显着升高（增加超过 10%）的患者被归类为第 1 组，而术后 BMI 水平下降的患者则被归为第 1 组。 BMI 有临床显着降低（降低超过 5%）的患者被归为第 2 组。使用 Spearman 相关分析来检验生活质量评分与术后临床参数之间的相关性。Spearman 相关分析显示，术后BMI、晚期并发症和无导管状态与 MSSCU 患者术后总体生活质量和症状量表以及 IC 患者术后总体生活质量和身体量表显着相关。此外，术后 BMI、无导管状态和辅助治疗的使用与许多生活质量指标的不良表现相关，如身体形象、未来视角、社会尺度、未来视角 (MSSCU) 和腹胀 (IC)（表 2） ，p<0.05）。在 IC 和 MSSCU 患者中，与第 1 组患者相比，体重显着减轻的第 2 组患者具有更好的整体生活质量、更低的造口狭窄发生率和更高的无导管状态。第2组的MSSCU患者可以达到与第1组的IC患者相当的整体生活质量。控制术后体重的大幅增加有助于改善生活质量，减少造口狭窄的发生，并确保BCa术后无导管状态接受 MSSCU 的患者。© 2023 作者。约翰·威利出版的癌症医学

To explore the influence of postoperative body mass index (BMI) change on postoperative quality of life (QOL) in patients undergoing radical cystectomy (RC) plus modified single stoma cutaneous ureterostomy (MSSCU) or ileal conduit (IC).Patients were divided into two groups according to different BMI change patterns: patients experiencing an elevated postoperative BMI level, along with a clinically significant increase in their BMI (an increase of more than 10%) were categorized as Group 1, while patients experiencing a decrease postoperative BMI level, along with a clinically significant reduction in their BMI (a decrease of more than 5%) were categorized as Group 2. Spearman correlation analysis was used to examine the correlations between quality-of-life scores and postoperative clinical parameters.Spearman correlation analysis showed that postoperative BMI, late complications and catheter-free state were significantly associated with postoperative global QoL and symptom scale in MSSCU and postoperative global QoL and physical scale in IC patients. Additionally, postoperative BMI, catheter-free state and the use of adjuvant therapy were associated with bad performance in many scales of QoL like body image, future perspective, social scale, future perspective (MSSCU), and abdominal bloating (IC) (Table 2, p<0.05). Patients in Group 2 with significant weight loss had a better Global QoL, a lower rate of stomal stricture and a higher catheter-free state compared with those in Group 1 in both IC and MSSCU patients. MSSCU patients in Group 2 could achieve a comparable Global QoL as to IC patients in Group 1.Controlling the substantial increase in body weight after surgery contributes to improving QoL, reducing the occurrence of stomal stricture, and ensuring a postoperative catheter-free state in BCa patients undergoing MSSCU.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.