Mallotumides A-C：来自 Mallotus spodocarpus 根部的强效细胞毒性环七肽。
Mallotumides A-C: Potent Cytotoxic Cycloheptapeptides from the Roots of Mallotus spodocarpus.
发表日期：2023 Oct 30
作者：
Natthapat Sawektreeratana, Chongkon Krachangchaeng, Prapadsorn Pittayanurak, Nolan M Betterley, Arthit Chairoungdua, Anongnat Wongpan, Wittaya Panvongsa, Pattarapapa Janthakit, Phattananawee Nalaoh, Vinich Promarak, Narong Nuntasaen, Vichai Reutrakul, Chutima Kuhakarn, Sakchai Hongthong
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
通过广泛的光谱分析阐明了从 Mallotus spodocarpus Airy Shaw 的根中分离出的强效细胞毒性环七肽，mallotumides A-C（分别为 1-3）的结构。 1的绝对构型由单晶X射线晶体学数据确定。所有三种环七肽均对多种癌细胞系表现出有效的细胞毒性，IC50 值范围为 0.60 至 4.02 nM。
The structures of potent cytotoxic cycloheptapeptides, mallotumides A-C (1-3, respectively) isolated from the roots of Mallotus spodocarpus Airy Shaw, were elucidated by extensive spectroscopic analysis. The absolute configuration of 1 was determined by single-crystal X-ray crystallographic data. All three cycloheptapeptides exhibited potent cytotoxicity against various cancer cell lines with IC50 values ranging from 0.60 to 4.02 nM.