背景：脂多糖（LPS）是某些类型细菌的组成部分，可以引起体内（包括胰腺）的炎症反应。大麻二酚 (CBD) 是大麻中发现的一种非精神活性化合物，已被证明具有抗炎作用，并可能为涉及炎症和损伤的疾病提供潜在的治疗益处。本研究的目的是调查 CBD 对实验性 LPS 诱导的大鼠胰腺病理学的潜在预防作用。材料和方法：32 只大鼠随机分为四组：对照组、LPS（5mg/kg，腹腔注射）、LPS CBD 和 CBD（5mg/kg，i.p.）组。给予LPS后6小时，将大鼠安乐死，采集血液和胰腺组织样本进行生化、聚合酶链反应(PCR)、组织病理学和免疫组织化学检查。结果：结果表明，LPS 降低了血清葡萄糖水平并增加了脂肪酶水平。组织病理学检查还导致严重充血、内分泌细胞空泡化增加、水肿和轻微炎症细胞浸润。免疫组织化学分析期间胰岛素和胰岛淀粉样多肽的表达下降。 PCR 分析显示，LPS 组中沉默信息调节因子 2 同源物 1 和过氧化物酶体增殖物激活受体 γ 辅激活因子 1 α 表达降低，肿瘤蛋白 p53 表达增加。 CBD 改善了生化、PCR、组织病理学和免疫组织化学结果。结论：目前的研究结果表明，LPS 会损害内分泌和外分泌胰腺。然而，CBD 在 LPS 诱导的大鼠模型胰腺炎中表现出显着的胰腺改善作用。

Background: Lipopolysaccharides (LPSs) are a component of certain types of bacteria and can induce an inflammatory response in the body, including in the pancreas. Cannabidiol (CBD), a nonpsychoactive compound found in cannabis, has been shown to have anti-inflammatory effects and may offer potential therapeutic benefits for conditions involving inflammation and damage. The aim of this study was to investigate any potential preventative effects of CBD on experimental LPS-induced pancreatic pathology in rats. Materials and Methods: Thirty-two rats were randomly divided into four groups as control, LPS (5 mg/kg, intraperitoneally [i.p.]), LPS+CBD, and CBD (5 mg/kg, i.p.) groups. Six hours after administering LPS, the rats were euthanized, and blood and pancreatic tissue samples were taken for biochemical, polymerase chain reaction (PCR), histopathological, and immunohistochemical examinations. Results: The results indicated that LPS decreased serum glucose levels and increased lipase levels. It also caused severe hyperemia, increased vacuolization in endocrine cells, edema, and slight inflammatory cell infiltrations at the histopathological examination. Insulin and amylin expressions decreased during immunohistochemical analyses. At the PCR analysis, Silent Information Regulator 2 homolog 1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha expressions decreased and tumor protein p53 expressions increased in the LPS group. CBD improved the biochemical, PCR, histopathological, and immunohistochemical results. Conclusions: The findings of the current investigation demonstrated that LPS damages both the endocrine and exocrine pancreas. However, CBD demonstrated marked ameliorative effects in the pancreas in LPS induced rat model pancreatitis.