描述一名患有急性髓性白血病的患者，该患者在巩固性外周血干细胞移植前后并发慢性移植物抗宿主病，出现复发性双侧外层视网膜病变。这是对 23 年记录的回顾性回顾- 患有急性髓性白血病的老年妇女，接受了一年多的全面眼科评估，包括彩色视野检查和多焦视网膜电图、谱域光学相干断层扫描成像、近红外和短波长眼底反射和自发荧光、荧光素和光学相干断层扫描血管造影。患者出现复发性单侧旁中心暗点。双眼中央周围视网膜内段椭球（EZ）和光感受器外段信号（IZ）局部丢失，与近红外反射率的高反射病变共定位。在接受巩固性外周血干细胞移植并并发类固醇抵抗性慢性移植物抗宿主病一年后，她随后右眼视力丧失（视力 = 20/200）。 EZ 和 IZ 信号丢失，对应于密集的中央锥体暗点和多焦视网膜电图凹陷。近红外自发荧光、荧光素和光学相干断层扫描血管造影均在正常范围内。口服泼尼松和静脉注射利妥昔单抗后，随着 EZ/IZ 信号的恢复，视力 (20/20) 和视网膜敏感性得到改善，但留下了残留的光感受器损失和旁中央暗点。我们认为，免疫介导的微血管病可能解释了这种长期、复发性的现象。该患者的原发性光感受器异常的病程，由于巩固性外周血干细胞移植后出现慢性移植物抗宿主病的表现而变得更加复杂。先前在白血病中记录的外视网膜发现可以通过类似的机制来解释。

To describe a patient with acute myelogenous leukemia who presented with a recurrent, bilateral, outer retinopathy, before and after consolidative peripheral blood stem cell transplantation complicated by chronic graft-versus-host disease.This is a retrospective review of records from a 23-year-old woman with acute myelogenous leukemia who underwent comprehensive ophthalmic evaluations for over a year including chromatic perimetry and multifocal electroretinograms, imaging with spectral domain optical coherence tomography, near-infrared and short-wavelength fundus reflectance and autofluorescence, fluorescein and optical coherence tomography angiography.The patient presented with recurrent, unilateral paracentral scotomas. There was localized loss of inner segment ellipsoid (EZ) and photoreceptor outer segment signals (IZ) in the pericentral retina of both eyes co-localizing with hyperreflective lesions on near-infrared reflectance. She subsequently lost vision (visual acuity = 20/200) in the right eye a year after consolidative peripheral blood stem cell transplantation complicated by steroid-resistant-chronic graft-versus-host disease. There was loss of the EZ and IZ signals corresponding to a dense central cone scotoma and multifocal electroretinograms depression. Near-infrared autofluorescence, fluorescein and optical coherence tomography angiography were within normal limits. Visual acuity (20/20) and retinal sensitivities improved with restoration of the EZ/IZ signals after oral prednisone and intravenous rituximab, but left a residual photoreceptor loss and paracentral scotoma.We propose that an immune-mediated microangiopathy may explain the protracted, recurrent course of primary photoreceptor abnormalities in our patient, which was further complicated by manifestations of chronic graft-versus-host disease following consolidative peripheral blood stem cell transplantation. Outer retinal findings previously documented in leukemia may be explained by a similar mechanism.