微波动力治疗（MDT）的新理念解决了临床上微波热疗（MWTT）非选择性加热、温度分布不均匀导致肿瘤根除不彻底，但微波敏化剂输送不畅和肿瘤缺氧障碍的问题。微环境限制了MDT的有效性。在此，我们设计了一种以共晶镓铟（EGaIn）为核心的液态金属纳米酶LM@ZIF@HA（LZH），其表面涂覆有CoNi-双金属沸石咪唑骨架（ZIF）和透明质酸（HA）。液态金属的灵活性和HA的靶向性使纳米酶能够被肿瘤细胞有效内吞，解决了微波敏化剂递送不良的问题。由于纳米酶具有类过氧化氢酶活性，在微波照射下催化肿瘤微环境中过量的H2O2产生O2，缓解肿瘤缺氧微环境的限制并促进ROS的产生。在体外细胞实验中，纳米酶具有显着的靶向作用、产氧能力和微波动力效应，有效解决了MDT的缺陷。在构建的患者来源的异种移植（PDX）模型中，尽管肿瘤模型具有与患者的组织学和病理特征相似的异质性和复杂性，但纳米酶仍取得了优异的MDT效果。 LZH  MW组肿瘤体积仅为对照组的1/20左右，抑瘤率高达95%。合成的纳米酶有效解决了MDT的缺陷，提高了微波敏化剂的靶向递送同时调节肿瘤缺氧微环境，在构建的PDX模型中取得了优异的MDT效果，为临床癌症治疗提供了新策略。© 2023。作者。

The novel concept of microwave dynamic therapy (MDT) solves the problem of incomplete tumor eradication caused by non-selective heating and uneven temperature distribution of microwave thermal therapy (MWTT) in clinic, but the poor delivery of microwave sensitizer and the obstacle of tumor hypoxic microenvironment limit the effectiveness of MDT.Herein, we engineer a liquid metal-based nanozyme LM@ZIF@HA (LZH) with eutectic Gallium Indium (EGaIn) as the core, which is coated with CoNi-bimetallic zeolite imidazole framework (ZIF) and hyaluronic acid (HA). The flexibility of the liquid metal and the targeting of HA enable the nanozyme to be effectively endocytosed by tumor cells, solving the problem of poor delivery of microwave sensitizers. Due to the catalase-like activity, the nanozyme catalyze excess H2O2 in the tumor microenvironment to generate O2, alleviating the restriction of the tumor hypoxic microenvironment and promoting the production of ROS under microwave irradiation. In vitro cell experiments, the nanozyme has remarkable targeting effect, oxygen production capacity, and microwave dynamic effect, which effectively solves the defects of MDT. In the constructed patient-derived xenograft (PDX) model, the nanozyme achieves excellent MDT effect, despite the heterogeneity and complexity of the tumor model that is similar to the histological and pathological features of the patient. The tumor volume in the LZH + MW group is only about 1/20 of that in the control group, and the tumor inhibition rate is as high as 95%.The synthesized nanozyme effectively solves the defects of MDT, improves the targeted delivery of microwave sensitizers while regulating the hypoxic microenvironment of tumors, and achieves excellent MDT effect in the constructed PDX model, providing a new strategy for clinical cancer treatment.© 2023. The Author(s).