经过手术治疗的低级别胶质瘤（LGG）患者通常功能良好且预后良好。然而，LGG 会影响神经认知功能。迄今为止，人们对这些患者的社会认知 (SC) 知之甚少，尽管 SC 受损与社会行为问题和社会参与度差有关。额叶脑区对于 SC 很重要，LGG 经常有额叶位置。因此，本研究的目的是探讨 LGG 患者术后和开始前的情绪识别（SC 的关键组成部分）是否受损，并与一般认知、肿瘤位置偏侧性、肿瘤体积和组织病理学特征相关。 121 名 LGG 患者与 169 名健康对照 (HC) 相匹配。通过 MRI 扫描确定肿瘤位置（包括（额叶）亚区域；岛叶、前扣带皮层、外侧前额叶皮层 (LPFC)、眶额-腹内侧 PFC）和肿瘤体积。情绪识别通过情绪刺激面部表情和测试 (FEEST) 的 Ekman 60 面孔测试进行测量。LGG 患者在 FEEST 上的表现显着低于 HC，其中 33.1% 的患者与正常数据相比表现出障碍。情绪识别与额叶肿瘤位置、偏侧性和组织病理学特征不显着相关，与一般认知和肿瘤体积显着但微弱相关。 LGG 患者情绪识别受损，但与特定肿瘤特征或一般认知不（强）相关。因此，无论肿瘤特征如何，通过对这些患者进行个体神经心理学评估来测量 SC 至关重要，以告知临床医生可能的损伤，从而提供适当的护理。© 作者 2023。由牛津大学出版社代表协会出版用于神经肿瘤学。

Patients with low-grade gliomas (LGG) treated with surgery, generally function well and have a favourable prognosis. However, LGG can affect neurocognitive functioning. To date, little is known about social cognition (SC) in these patients, although impaired SC is related to social-behavioral problems and poor societal participation. Frontal brain areas are important for SC and LGG frequently have a frontal location. Therefore, the aim of the present study was to investigate whether emotion recognition, a key component of SC, was impaired, and related to general cognition, tumor location laterality, tumor volume and histopathological characteristics in patients with LGG, post-surgery and before start of adjuvant therapy.121 patients with LGG were matched with 169 healthy controls (HC). Tumor location (including (frontal) subregions; insula, anterior cingulate cortex, lateral prefrontal cortex (LPFC), orbitofrontal-ventromedial PFC) and tumor volume were determined on MRI scans. Emotion recognition was measured with the Ekman 60 faces test of the Facial Expressions of Emotion-Stimuli and Tests (FEEST).Patients with LGG performed significantly lower on the FEEST than HC, with 33.1% showing impairment compared to norm data. Emotion recognition was not significantly correlated to frontal tumor location, laterality and histopathological characteristics, and significantly but weakly with general cognition and tumor volume.Emotion recognition is impaired in patients with LGG but not (strongly) related to specific tumor characteristics or general cognition. Hence, measuring SC with individual neuropsychological assessment of these patients is crucial, irrespective of tumor characteristics, to inform clinicians about possible impairments, and consequently offer appropriate care.© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.