程序性细胞死亡配体 1 (PDL1) 在许多癌症中具有预测和预后价值。本研究旨在探讨III期乳腺癌（BC）中PDL1的表达及其与临床结局的相关性。采用免疫组织化学（IHC）法测定肿瘤组织中PDL1的蛋白表达。 PDL1 和临床病理变量之间的相关性通过 χ2 检验或 Fisher 精确检验进行。 Cox比例风险模型用于潜在预后因素的单变量和多变量分析。基于Kaplan-Meier分析估计生存曲线，并采用Log Rank检验对比影响生存结果的因素。根据PDL1表达半定量评分方法，将患者分为PDL1低表达组（109例） PDL1高表达组（107例）。 PDL1表达与淋巴结阳性、腋窝淋巴结阳性、术后放疗、CK5/6表达相关（P < 0.05）。肿瘤组织中的 PDL1 表达被发现是 III 期 BC 的无病生存期 (DFS) 和总生存期 (OS) 的潜在预后危险因素。此外，与总患者群体中 PDL1 表达低的患者相比，PDL1 高表达的患者显示出更长的生存期（DFS 和 OS）（P < 0.05）。此外，列线图显示预测线与术后 1 年、3 年和 5 年寿命的参考线非常一致。 DCA曲线显示，通过列线图预测3年和5年寿命比仅通过PDL1更好地预测临床应用。PDL1是III期BC的潜在预后因素，与一些临床病理特征密切相关。肿瘤组织中的 PDL1 表达与 BC III 期更好的生存率显着相关。© 2023 张等人。

Programmed cell death ligand 1 (PDL1) has the predictive and prognostic value in a great deal of cancers. This study aims to explore the expression of PDL1 in stage III breast cancer (BC) and its correlation with clinical outcome.The protein expression of PDL1 in tumor tissues was determined by immunohistochemistry (IHC). The correlations between PDL1 and clinicopathological variables were performed by χ²-tests or Fisher's exact tests. The Cox proportional hazards model was used for univariate and multivariate analysis of the potential prognostic factors. Survival curves were estimated based on Kaplan-Meier analyses, and Log Rank test was used to contrast factors influencing the survival outcome.On the basis of the semiquantitative scoring method for PDL1 expression, the patients were divided into low PDL1 expression group (109 cases) and high PDL1 expression group (107 cases). PDL1 expression was correlated with positive lymph nodes, positive axillary lymph nodes, postoperative radiotherapy, and CK5/6 expression (P < 0.05). The PDL1 expression in tumor tissues was discovered to be a potential prognostic risk factor with the disease-free survival (DFS) and overall survival (OS) for stage III BC. Moreover, patients with high PDL1 expression showed longer lifetime (DFS and OS) compared to those with low PDL1 expression in total patient population (P < 0.05). Moreover, the nomogram showed that the prediction line is in good agreement with the reference line for postoperative 1-, 3-, and 5-year lifetime. The DCA curve showed that the 3- and 5-year lifetime by nomogram had so much better divination of the clinical application than only by PDL1.PDL1 is a latent prognostic factor in stage III BC and is closely related to some clinicopathological features. PDL1 expression in tumor tissues is significantly associated with better lifetime rate in stage III BC.© 2023 Zhang et al.